Genetic Diversity of the KIR/HLA System and Susceptibility to Hepatitis C Virus-Related Diseases
Fig 2
Centromeric and telomeric halves of KIR genotypes (panel A).
A stretch of 14 kb DNA that interconnects KIR3DP1 and KIR2DL4 divides the KIR genotype into two halves. The centromeric half is delimited by 3DL3 and 3DP1, while the telomeric half is delimited by 2DL4 and 3DL2. There is different KIR gene content, due to a recombination of these genes, in KIR genotypes across individuals and populations. The framework genes, present in all genotypes are shown in grey boxes; genes encoding activating KIR are in red color; and those for inhibitory receptors are in blue color. KIR2DL4 encodes a receptor that has both inhibitory and activating functions The KIR2DP1 and 3DP1 (green) are pseudogenes that do not express a receptor. Pairwise D’ LD based on Cramer’s V correlation coefficient between the presence and absence of different KIR genes in four groups of patients (panel B-E) B: HCV negative; C: Chronic HCV; D: Hepatocellular carcinoma; E: Lymphoproliferative disease. The KIR cluster genetic polymorphism is considered as the presence or absence of KIR genes.
