Dynamical analysis of the effects of circadian clock on the neurotransmitter dopamine

Ying Li; Zhao Zhao; Yuan-yuan Tan; Xue Wang; Ying Li; Zhao Zhao; Yuan-yuan Tan; Xue Wang

doi:10.3934/mbe.2023742

Mathematical Biosciences and Engineering

2023, Volume 20, Issue 9: 16663-16677. doi: 10.3934/mbe.2023742

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Research article

Dynamical analysis of the effects of circadian clock on the neurotransmitter dopamine

1.
College of Information Technology, Shanghai Ocean University, Shanghai 201306, China
2.
Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 203306, China

Academic Editor: Yang Kuang

Received: 06 June 2023 Revised: 20 July 2023 Accepted: 27 July 2023 Published: 21 August 2023

The circadian clock is an autonomous timing system that regulates the physiological and behavioral activities of organisms. Dopamine (DA) is an important neurotransmitter that is associated with many biological activities such as mood and movement. Experimental studies have shown that the circadian clock influences the DA system and disorders in the circadian clock lead to DA-related diseases. However, the regulatory mechanism of the circadian clock on DA is far from clear. In this paper, we apply an existing circadian-dopamine mathematical model to explore the effects of the circadian clock on DA. Based on numerical simulations, we find the disturbance of the circadian clock, including clock gene mutations, jet lag and light pulses, leads to abnormal DA levels. The effects of mutations in some clock genes on the mood and behavior of mice are closely related to DA disruptions. By sensitivity analysis of DA levels to parameter perturbation, we identify key reactions that affect DA levels, which provides insights into modulating DA disorders. Sudden changes in external light influence the circadian clock, bringing about effects on the DA system. Jet lag causes transient DA rhythm desynchronization with the environment and the influence of jet lag in different directions on DA level and phase varies. Light pulses affect the amplitude and phase shift of DA, which provides a promising method for treating DA disorders through light exposure. This study helps to better understand the impact of the circadian clock on the DA system and provides theoretical support for the treatment of DA disorders.
- circadian clock,
- dopamine,
- mathematical model,
- phase shift,
- jet lag,
- phase response curve,
- amplitude response curve
Citation: Ying Li, Zhao Zhao, Yuan-yuan Tan, Xue Wang. Dynamical analysis of the effects of circadian clock on the neurotransmitter dopamine[J]. Mathematical Biosciences and Engineering, 2023, 20(9): 16663-16677. doi: 10.3934/mbe.2023742

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Abstract

The circadian clock is an autonomous timing system that regulates the physiological and behavioral activities of organisms. Dopamine (DA) is an important neurotransmitter that is associated with many biological activities such as mood and movement. Experimental studies have shown that the circadian clock influences the DA system and disorders in the circadian clock lead to DA-related diseases. However, the regulatory mechanism of the circadian clock on DA is far from clear. In this paper, we apply an existing circadian-dopamine mathematical model to explore the effects of the circadian clock on DA. Based on numerical simulations, we find the disturbance of the circadian clock, including clock gene mutations, jet lag and light pulses, leads to abnormal DA levels. The effects of mutations in some clock genes on the mood and behavior of mice are closely related to DA disruptions. By sensitivity analysis of DA levels to parameter perturbation, we identify key reactions that affect DA levels, which provides insights into modulating DA disorders. Sudden changes in external light influence the circadian clock, bringing about effects on the DA system. Jet lag causes transient DA rhythm desynchronization with the environment and the influence of jet lag in different directions on DA level and phase varies. Light pulses affect the amplitude and phase shift of DA, which provides a promising method for treating DA disorders through light exposure. This study helps to better understand the impact of the circadian clock on the DA system and provides theoretical support for the treatment of DA disorders.

References

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