Radiation Oncology/CNS/Introduction
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Survival
[edit | edit source]2-year and 5-year OS of various primary CNS tumors:
- Astrocytoma, Pilocytic WHO grade I - 90%
- Astrocytoma WHO grade II - 66%
- Astrocytoma WHO grade III - 45% and 34%
- GBM - 9%
- Oligodendroglioma - 81% and 65%
- Medulloblastoma - 66% and 60%
- Ependymoma - 83% and 60%
Tumors that might be irradiated without pathologic diagnosis
[edit | edit source]- Optic glioma
- Diffuse pontine glioma
- Meningioma
- Choroidal melanoma
CNS tumors that are most likely to metastasize outside the CNS
[edit | edit source]- Glioblastoma
- Medulloblastoma
- Ependymoma
- Hemangiopericytoma
- Meningioma
Pathologic correlations
[edit | edit source]- Rosenthal fibers - JPA
- Psammoma bodies - meningioma (and papillary tumors such as thyroid or endometrial)
- Verocay bodies - schwannoma
- Schiller Duval body - yolk sac tumor
- Fried egg appearance - oligodendroglioma
- Pseudorosettes (central lumen not formed by the growth itself, unlike a rosette) - ependymoma, but also PNET, medulloblastoma
- Homer-Wright rosette - PNET, medulloblastoma, pineoblastoma, neuroblastoma
- Flexner-Wintersteiner rosette - retinoblastoma
