IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy.

Hatzivassiliou G; Miller I; Takizawa J; Palanisamy N; Rao PH; Iida S; Tagawa S; Taniwaki M; Russo J; Neri A; Cattoretti G; Clynes R; Mendelsohn C; Chaganti RS; Dalla-Favera R

doi:10.1016/s1074-7613(01)00109-1

IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy.

Rao PH ,

Iida S ,

Neri A ,

Affiliations

1. Institute of Cancer Genetics, Columbia University, New York, NY 10032, USA.
Authors
Hatzivassiliou G¹
(1 author)

ORCIDs linked to this article

Immunity, 01 Mar 2001, 14(3):277-289
https://doi.org/10.1016/s1074-7613(01)00109-1 PMID: 11290337

Abstract

Abnormalities of chromosome 1q21 are common in B cell malignancies, but their target genes are largely unknown. By cloning the breakpoints of a (1;14) (q21;q32) chromosomal translocation in a myeloma cell line, we have identified two novel genes, IRTA1 and IRTA2, encoding cell surface receptors homologous to the Fc and inhibitory receptor families. Both genes are selectively expressed in mature B cells: IRTA1 in marginal zone B cells and IRTA2 in centrocytes, marginal zone B cells, and immunoblasts. As a result of the t(1;14), IRTA1 is fused to the immunoglobulin Calpha domain to produce a chimeric IRTA1/Calpha fusion protein. In tumor cell lines with 1q21 abnormalities, IRTA2 expression is deregulated. Thus, IRTA1 and IRTA2 are novel immunoreceptors implicated in B cell development and lymphomagenesis.

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Diseases in OMIM (3)

Fc RECEPTOR-LIKE PROTEIN 5; FCRL5(OMIM - 605877)
Fc RECEPTOR-LIKE PROTEIN 4; FCRL4(OMIM - 605876)
IgA CONSTANT HEAVY CHAIN 1; IGHA1(OMIM - 146900)

Proteins in UniProt (3)

Immunoglobulin heavy constant alpha 1(UniProt - P01876)
Fc receptor-like protein 4(UniProt - Q96PJ5)
Fc receptor-like protein 5(UniProt - Q96RD9)

GlyGen is an international glycobioinformatics knowledgebase funded by The National Institutes of Health to facilitate glycoscience research by integrating diverse kinds of information, including glycomics, genomics, proteomics (and glycoproteomics), cell biology, developmental biology and biochemistry.

https://www.glygen.org/publication/MED/11290337

Nucleotide sequences in ENA (Showing 5 of 16)

Homo sapiens (human) partial immunoglobulin superfamily receptortranslocation associated protein 2d(ENA - AAK31328)
Homo sapiens (human) immunoglobulin superfamily receptor translocationassociated protein 2c(ENA - AAK31327)
Homo sapiens (human) immunoglobulin superfamily receptor translocationassociated protein 1a(ENA - AAK31324)
Homo sapiens (human) immunoglobulin superfamily receptor translocationassociated protein 2b(ENA - AAK31326)
Homo sapiens (human) translocation associated fusion protein IRTA1/IGA1(ENA - AAK31329)

Go to all (16) records in ENA

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Associazione Italiana per la Ricerca sul Cancro

NCI NIH HHS (4)

Grant ID: CA37295
24 publications
Grant ID: CA66699
2 publications
Grant ID: CA34775
21 publications
Grant ID: CA80814
2 publications

National Institutes of Health (4)

Grant ID: CA66699
1 publication
Grant ID: CA34775
1 publication
Grant ID: CA37295
1 publication
Grant ID: CA80814
1 publication

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IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy.

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Molecular biology of lymphomas

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Associazione Italiana per la Ricerca sul Cancro

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