Integrins as a distinct subtype of dependence receptors.

Stupack DG

doi:10.1038/sj.cdd.4401658

Abstract

In the absence of their cognate ligand, dependence receptors trigger programmed cell death. This function is the defining feature of dependence receptors, which include members of several different protein families. The integrins are a family of heterodimeric receptors for extracellular matrix (ECM) proteins, mediating cell anchorage and migration. Integrins share characteristics with dependence receptors, and integrin binding to substrate ECM ligands is essential for cell survival. Although integrins do not conform in all characteristics to the established definitions of dependence receptors, alterations in the expression of integrins and their ligands during physiological and pathological events, such as wound healing, angiogenesis and tumorigenesis, do regulate cell fate in a ligand-dependent manner. This biosensory function of integrins fits well with our current concept of dependence receptor action, and thus integrins may rightly be considered to comprise a distinct subclass of dependence receptor.

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NCI NIH HHS (1)

Grant ID: R01 CA107263
38 publications

Search life-sciences literature (45,103,589 articles, preprints and more)

Integrins as a distinct subtype of dependence receptors.

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Authors

Abstract

Full text links

References

Receptor protein tyrosine kinases and phosphatases.

Title not supplied

Tissue structure, nuclear organization, and gene expression in normal and malignant breast.

The extracellular matrix as a cell survival factor.

Control of motile and invasive cell phenotypes by focal adhesion kinase.

Adhesion-mediated intracellular redistribution of c-Fas-associated death domain-like IL-1-converting enzyme-like inhibitory protein-long confers resistance to CD95-induced apoptosis in hematopoietic cancer cell lines.

Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis.

Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase.

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase.

Engagement of the alpha2beta1 integrin inhibits Fas ligand expression and activation-induced cell death in T cells in a focal adhesion kinase-dependent manner.

Citations & impact

Impact metrics

Citations of article over time

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Article citations

Collagen I Increases Palmitate-Induced Lipotoxicity in HepG2 Cells via Integrin-Mediated Death.

Development of antibacterial collagen membranes with optimal silver nanoparticle content for periodontal regeneration.

Identification of basement membrane markers in diabetic kidney disease and immune infiltration by using bioinformatics analysis and experimental verification.

Cardiac Differentiation Promotes Focal Adhesions Assembly through Vinculin Recruitment.

Netrin-4: Focus on Its Role in Axon Guidance, Tissue Stability, Angiogenesis and Tumors.

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