11C-SCH 39166, a selective ligand for visualization of dopamine-D1 receptor binding in the monkey brain using PET.

Sedvall G; Farde L; Barnett A; Hall H; Halldin C

doi:10.1007/bf02244195

Abstract

The new selective D1-dopamine receptor antagonist SCH 39166 was labelled with the positron emitting isotope 11C and used as ligand for visualization of dopamine-D1 receptor binding in Cynomolgus monkeys by PET. After intravenous administration of the ligand a marked uptake of radioactivity was recorded in the D1-dopamine receptor-rich striatum and neocortex but not in the dopamine receptor-poor cerebellum. The uptake of radioactivity in striatum and neocortex was markedly displaced after the intravenous injection of a high dose of the D1-dopamine receptor antagonist SCH 23390 but not after the 5-HT2 receptor antagonist ketanserine. 11C-SCH 39166 should be a useful tool to explore D1-dopamine receptor characteristics in the living human brain by PET.

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References

Articles referenced by this article (14)

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Characterization of the binding of 3H-SCH 23390, a selective D-1 receptor antagonist ligand, in rat striatum.
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Farde L, Halldin C, Stone-Elander S, Sedvall G
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MED: 2957716
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Hall H, Farde L, Sedvall G
J Neural Transm, (1):7-21 1988
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Preparation of 11C-labelled SCH 23390 for the in vivo study of dopamine D-1 receptors using positron emission tomography.
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Halldin C, Farde L, Barnett A, Sedvall G (1990) Preparation of (11C)SCH 39166, a new selective D1-dopamine receptor ligand for PET. J Nucl Med 31:737
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Eur J Nucl Med, (11):719-721 1989
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SCH 23390 - the first selective dopamine D-1 antagonist.
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Eur J Pharmacol, (1):153-154 1983
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Grant ID: NIMH 48414
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11C-SCH 39166, a selective ligand for visualization of dopamine-D1 receptor binding in the monkey brain using PET.

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Abstract

Full text links

References

Characterization of the binding of 3H-SCH 23390, a selective D-1 receptor antagonist ligand, in rat striatum.

[18F]setoperone: a new high-affinity ligand for positron emission tomography study of the serotonin-2 receptors in baboon brain in vivo.

Pharmacological profile of SCH39166: a dopamine D1 selective benzonaphthazepine with potential antipsychotic activity.

PET analysis of human dopamine receptor subtypes using 11C-SCH 23390 and 11C-raclopride.

Human dopamine receptor subtypes--in vitro binding analysis using 3H-SCH 23390 and 3H-raclopride.

Preparation of 11C-labelled SCH 23390 for the in vivo study of dopamine D-1 receptors using positron emission tomography.

Halldin C, Farde L, Barnett A, Sedvall G (1990) Preparation of (11C)SCH 39166, a new selective D1-dopamine receptor ligand for PET. J Nucl Med 31:737

A preliminary evaluation of the Scanditronix PC2048-15B brain scanner.

SCH 23390 - the first selective dopamine D-1 antagonist.

Citations & impact

Impact metrics

Citations of article over time

Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1007/bf02244195

Article citations

Molecular Imaging of Opioid and Dopamine Systems: Insights Into the Pharmacogenetics of Opioid Use Disorders.

Small Molecule Receptor Ligands for PET Studies of the Central Nervous System-Focus on G Protein Coupled Receptors.

Pharmacology of signaling induced by dopamine D(1)-like receptor activation.

Investigating the dopaminergic synapse in vivo. II. Molecular imaging studies in small laboratory animals.

Probing cortical dopamine function in schizophrenia: what can D1 receptors tell us?

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11C-SCH 39166, a selective ligand for visualization of dopamine-D1 receptor binding in the monkey brain using PET.

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Halldin C, Farde L, Barnett A, Sedvall G (1990) Preparation of (11C)SCH 39166, a new selective D1-dopamine receptor ligand for PET. J Nucl Med 31:737

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