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Magnetic field tomography of coherent thalamocortical 40-Hz oscillations in humans.

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  • 1. Department of Physiology and Biophysics, New York University Medical Center, NY 10016.
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    • Ribary U 1
    (1 author)

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Proceedings of the National Academy of Sciences of the United States of America, 01 Dec 1991, 88(24):11037-11041
https://doi.org/10.1073/pnas.88.24.11037 PMID: 1763020 PMCID: PMC53068

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Abstract 

This paper introduces the use of magnetic field tomography (MFT), a noninvasive technique based on distributed source analysis of magnetoencephalography data, which makes possible the three-dimensional reconstruction of dynamic brain activity in humans. MFT has a temporal resolution better than 1 msec and a spatial accuracy of 2-5 mm at the cortical level, which deteriorates to 1-3 cm at depths of 6 cm or more. MFT is used here to visualize the origin of a spatiotemporally organized pattern of coherent 40-Hz electrical activity. This coherence, initially observed during auditory input, was proposed to be generated by recurrent corticothalamic oscillation. In support of this hypothesis, we illustrate well-defined 40-Hz coherence between cortical-subcortical sites with a time shift that is consistent with thalamocortical conduction times. Studies on Alzheimer patients indicate that, while a similar activity pattern is present, the cortical component is reduced in these subjects.

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Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24): 11037–11041.
PMCID: PMC53068
PMID: 1763020

Magnetic field tomography of coherent thalamocortical 40-Hz oscillations in humans.

U Ribary, A A Ioannides, K D Singh, R Hasson, J P Bolton, F Lado, A Mogilner, and R Llinás
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Abstract

This paper introduces the use of magnetic field tomography (MFT), a noninvasive technique based on distributed source analysis of magnetoencephalography data, which makes possible the three-dimensional reconstruction of dynamic brain activity in humans. MFT has a temporal resolution better than 1 msec and a spatial accuracy of 2-5 mm at the cortical level, which deteriorates to 1-3 cm at depths of 6 cm or more. MFT is used here to visualize the origin of a spatiotemporally organized pattern of coherent 40-Hz electrical activity. This coherence, initially observed during auditory input, was proposed to be generated by recurrent corticothalamic oscillation. In support of this hypothesis, we illustrate well-defined 40-Hz coherence between cortical-subcortical sites with a time shift that is consistent with thalamocortical conduction times. Studies on Alzheimer patients indicate that, while a similar activity pattern is present, the cortical component is reduced in these subjects.

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Selected References

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