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Niche regulation of muscle satellite cell self-renewal and differentiation.

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Affiliations

  • 1. The Sprott Center for Stem Cell Research, Regenerative Medicine Program, Ottawa Health Research Institute, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada.
      Authors
    • Kuang S 1
    (1 author)

ORCIDs linked to this article

Cell Stem Cell, 01 Jan 2008, 2(1):22-31
https://doi.org/10.1016/j.stem.2007.12.012 PMID: 18371418 

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Abstract 

Muscle satellite cells have been shown to be a heterogeneous population of committed myogenic progenitors and noncommitted stem cells. This hierarchical composition of differentiating progenitors and self-renewable stem cells assures the extraordinary regenerative capacity of skeletal muscles. Recent studies have revealed a role for asymmetric division in satellite cell maintenance and offer novel insights into the regulation of satellite cell function by the niche. A thorough understanding of the molecular regulation and cell fate determination of satellite cells and other potential stem cells resident in muscle is essential for successful stem cell-based therapies to treat muscular diseases.

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Read article at publisher's site: https://doi.org/10.1016/j.stem.2007.12.012

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Funding 

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Howard Hughes Medical Institute