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Biosafety in handling gene transfer vectors.

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Affiliations

  • 1. Harvard Medical School, Boston, Massachusetts, USA.
      Authors
    • Braun A 1
    (1 author)

Current Protocols in Human Genetics, 01 Aug 2006, Chapter 12:Unit 12.1
https://doi.org/10.1002/0471142905.hg1201s50 PMID: 18428388 

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Abstract 

This unit is devoted to safety issues that must be considered when generating and working with vectors for gene therapy. A short description of the relevant regulatory bodies and mechanisms is followed by a general discussion of containment and safety procedures. This is followed by vector-specific guidelines for nine commonly used vector systems, including adenovirus, vaccinia, HSV-1, lentivirus, and nonviral vectors. Recent tragic experiences with retroviral integration near oncogene loci demonstrate the surprise effects of successful gene therapy. The unit also outlines the problems encountered when taking a promising vector to clinical trials.

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Read article at publisher's site: https://doi.org/10.1002/0471142905.hg1201s50

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