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Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes.

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  • 1. Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland.
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    • Jongeneel CV 1
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Proceedings of the National Academy of Sciences of the United States of America, 01 Nov 1991, 88(21):9717-9721
https://doi.org/10.1073/pnas.88.21.9717 PMID: 1946393 PMCID: PMC52790

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Abstract 

We have identified three polymorphic microsatellites (which we call TNFa, TNFb, and TNFc) within a 12-kilobase region of the human major histocompatibility complex (MHC) that includes the tumor necrosis factor (TNF) locus. TNFc is located within the first intron of the TNF-beta gene and has only 2 alleles. TNFa and TNFb are 3.5 kilobases upstream (telomeric) of the TNF-beta gene and have at least 13 and 7 alleles, respectively. TNFa, -b, and -c alleles are in linkage disequilibrium with alleles at other loci within the MHC, including class I, class II, and class III. TNFa, -b, and -c alleles are also associated with extended HLA haplotypes. These TNF polymorphisms will allow a thorough genetic analysis of the involvement of TNF in MHC-linked pathologies.

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Proc Natl Acad Sci U S A. 1991 Nov 1; 88(21): 9717–9721.
PMCID: PMC52790
PMID: 1946393

Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes.

C V Jongeneel, L Briant, I A Udalova, A Sevin, S A Nedospasov, and A Cambon-Thomsen
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Abstract

We have identified three polymorphic microsatellites (which we call TNFa, TNFb, and TNFc) within a 12-kilobase region of the human major histocompatibility complex (MHC) that includes the tumor necrosis factor (TNF) locus. TNFc is located within the first intron of the TNF-beta gene and has only 2 alleles. TNFa and TNFb are 3.5 kilobases upstream (telomeric) of the TNF-beta gene and have at least 13 and 7 alleles, respectively. TNFa, -b, and -c alleles are in linkage disequilibrium with alleles at other loci within the MHC, including class I, class II, and class III. TNFa, -b, and -c alleles are also associated with extended HLA haplotypes. These TNF polymorphisms will allow a thorough genetic analysis of the involvement of TNF in MHC-linked pathologies.

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Selected References

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