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ENCEPHALOMYELITIS ACCOMPANIED BY MYELIN DESTRUCTION EXPERIMENTALLY PRODUCED IN MONKEYS.

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  • 1. Hospital of The Rockefeller Institute for Medical Research.
      Authors
    • Rivers TM 1
    (1 author)

The Journal of Experimental Medicine, 01 Apr 1935, 61(5):689-702
https://doi.org/10.1084/jem.61.5.689 PMID: 19870385 PMCID: PMC2133246

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Abstract 

The repeated intramuscular injections of aqueous emulsions and alcohol-ether extracts of sterile normal rabbit brains in some manner produced pathological changes accompanied by myelin destruction in the brains of 7 of 8 monkeys (Macacus rhesus). Eight, control monkeys remained well. Cultures from the involved brains remained sterile, and no transmissible agent was demonstrated by means of intracerebral inoculations of emulsions of bits of the brains into monkeys, rabbits, guinea pigs, and white mice.

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J Exp Med. 1935 Apr 30; 61(5): 689–702.
PMCID: PMC2133246
PMID: 19870385

ENCEPHALOMYELITIS ACCOMPANIED BY MYELIN DESTRUCTION EXPERIMENTALLY PRODUCED IN MONKEYS

Thomas M. Rivers and Francis F. Schwentker
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Abstract

The repeated intramuscular injections of aqueous emulsions and alcohol-ether extracts of sterile normal rabbit brains in some manner produced pathological changes accompanied by myelin destruction in the brains of 7 of 8 monkeys (Macacus rhesus). Eight, control monkeys remained well. Cultures from the involved brains remained sterile, and no transmissible agent was demonstrated by means of intracerebral inoculations of emulsions of bits of the brains into monkeys, rabbits, guinea pigs, and white mice.

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Selected References

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  • Stuart MC, Lazarus L. Standardisation of human chorionic gonadotropin, hCG subunits, and pregnancy tests. Lancet. 1982 May 15;1(8281):1123–1123. [Abstract] [Google Scholar]
  • Schwentker FF, Rivers TM. THE ANTIBODY RESPONSE OF RABBITS TO INJECTIONS OF EMULSIONS AND EXTRACTS OF HOMOLOGOUS BRAIN. J Exp Med. 1934 Oct 31;60(5):559–574. [Europe PMC free article] [Abstract] [Google Scholar]
Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

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