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Breast cancer stem cells: something out of notching?

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Affiliations

  • 1. Breast Biology Group, School of Cancer and Enabling Sciences, Paterson Institute for Cancer Research, University of Manchester;, Manchester, United Kingdom.
      Authors
    • Harrison H 1
    (1 author)

ORCIDs linked to this article

Cancer Research, 02 Nov 2010, 70(22):8973-8976
https://doi.org/10.1158/0008-5472.can-10-1559 PMID: 21045140 

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Abstract 

We and others have established that the developmental Notch receptor signaling pathway is active in breast cancer cell lines, as well as in preinvasive and invasive primary samples. Recently, a role for Notch in regulating the hierarchy of stem and progenitor cells in both normal and cancer epithelium has been elucidated. Because inhibiting the Notch receptor signaling pathway is a possible future breast cancer therapy, here, we review the expression and activity of the different ligands and receptors and summarize the various ways in which the pathway's activity can be inhibited, and the likely effects of inhibition on different tumor cell subpopulations.

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Read article at publisher's site: https://doi.org/10.1158/0008-5472.can-10-1559

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http://cancerres.aacrjournals.org/cgi/content/full/70/22/8973

Free to read at cancerres.aacrjournals.org
http://cancerres.aacrjournals.org/cgi/content/abstract/70/22/8973

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Funding 

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Breast Cancer Now (1)

Wellcome Trust