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Association of a lukM-positive clone of Staphylococcus aureus with fatal exudative dermatitis in red squirrels (Sciurus vulgaris).

Author information

Affiliations

  • 1. Wildlife Veterinary Investigation Centre, Jollys Bottom Farm, Chacewater, Truro, Cornwall TR4 8PB, United Kingdom.
      Authors
    • Simpson VR 1
    (1 author)
  • 2. Animal Health and Veterinary Laboratories Agency, Polwhele, Truro, Cornwall TR4 9AD, United Kingdom.
      Authors
    • Davison NJ 2
    (1 author)
  • 3. Laboratory of Healthcare Associated Infection, Microbiology Services Colindale, Health Protection Agency, 61 Colindale Avenue, London, NW9 5EQ, United Kingdom.
      Authors
    • Kearns AM 3
    • Pichon B 3
    (2 authors)
  • 4. Department of Infectious Disease Epidemiology, Imperial College London Old Medical School Building, St. Mary's Campus, London, W2 1PG, United Kingdom.
      Authors
    • Hudson LO 4
    (1 author)
  • 5. Department of Bacteriology, Animal Health and Veterinary Laboratories Agency, Weybridge, New Haw, Addlestone, Surrey, KT15 3NB, United Kingdom.
      Authors
    • Koylass M 5
    • Whatmore AM 5
    (2 authors)
    • Show all (8)

ORCIDs linked to this article

Veterinary Microbiology, 02 Nov 2012, 162(2-4):987-991
https://doi.org/10.1016/j.vetmic.2012.10.025 PMID: 23182436 

Abstract 

Fatal exudative dermatitis (FED) is a recently described condition affecting red squirrels (Sciurus vulgaris) on the Isle of Wight and Jersey (Simpson et al., 2010a). Staphylococcus aureus strains isolated from skin lesions in cases of FED were characterised by molecular and phenotypic approaches. The strains were found to belong to a single MLST clonal complex (CC49) representing either ST49 or a novel single locus variant thereof (ST1957), were closely related by other molecular typing approaches, and all possessed the leukotoxin M encoding gene (lukM). In contrast S. aureus was either not isolated from none-FED cases or belonged to distinct and diverse molecular types that, with one exception, did not encode lukM. All isolates from FED cases were susceptible to all antimicrobials tested, including penicillin, and all proved negative for mecA and mecC as well as 14 other staphylococcal toxin genes. As all squirrels affected by FED were infected with S. aureus of the same lineage and encoded the lukM gene, it is possible that strains of this lineage may be involved in the pathogenesis of the dermatitis.

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Read article at publisher's site: https://doi.org/10.1016/j.vetmic.2012.10.025

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Funding 

Funders who supported this work.

AHVLA Diseases of Wildlife Scheme

    AHVLA Research and Development Internal Investment Fund Project (1)

    Biotechnology and Biological Sciences Research Council (1)

    Channel Island Co-operative Society

      JSPCA Animals’ Shelter

        Jersey Ecology Trust Fund

          Moore Stephens