Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Thiopeptide engineering: a multidisciplinary effort towards future drugs.

Author information

Affiliations

  • 1. Institute for Research in Biomedicine, Barcelona Science Park, University of Barcelona, Baldiri Reixac 10, 08028 Barcelona (Spain) http://www.pcb.ub.edu/fama/htm/home.htm; CIBER-BBN, Networking Centre on Bioengineering Biomaterials and Nanomedicine, 08028 Barcelona (Spain).
      Authors
    • Just-Baringo X 1
    (1 author)

ORCIDs linked to this article

Angewandte Chemie (International ed. in English), 23 May 2014, 53(26):6602-6616
https://doi.org/10.1002/anie.201307288 PMID: 24861213 

Review

Abstract 

The recent development of thiopeptide analogues of antibiotics has allowed some of the limitations inherent to these naturally occurring substances to be overcome. Chemical synthesis, semisynthetic derivatization, and engineering of the biosynthetic pathway have independently led to complementary modifications of various thiopeptides. Some of the new substances have displayed improved profiles, not only as antibiotics, but also as antiplasmodial and anticancer drugs. The design of novel molecules based on the thiopeptide scaffold appears to be the only strategy to exploit the high potential they have shown in vitro. Herein we present the most relevant achievements in the production of thiopeptide analogues and also discuss the way the different approaches might be combined in a multidisciplinary strategy to produce more sophisticated structures.

Full text links 

Read article at publisher's site: https://doi.org/10.1002/anie.201307288

References 

Articles referenced by this article (104)

Show 10 more references (10 of 104)

Citations & impact 

Impact metrics

37
Citations
Jump to Citations

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/2375299
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/2375299

Article citations

Go to all (37) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.