The T-cell antigen receptor gamma gene: rearrangement and cell lineages.

Allison JP; Lanier LL

doi:10.1016/0167-5699(87)90014-4

The T-cell antigen receptor gamma gene: rearrangement and cell lineages.

Allison JP ¹,

Lanier LL ²

Affiliations

1. Cancer Research Laboratory, Department of Microbiology and Immunology, University of California, Berkeley, California 94720, USA.
Authors
Allison JP¹
(1 author)
2. Becton Dickinson Monoclonal Center, Inc., Mountain View, California 94043, USA.
Authors
Lanier LL²
(1 author)

ORCIDs linked to this article

Allison JP | 0000-0001-8980-5697

Immunology Today, 01 Jan 1987, 8(10):293-296
https://doi.org/10.1016/0167-5699(87)90014-4 PMID: 25290833

Abstract

Most adult T cells have a T-cell antigen receptor composed of αß heterodimers in a complex with the CD3 antigen. Immature thymocytes, however, can express CD3-associated heterodimers of a γ chain and another poorly characterized chain ('δ'). Here James Allison and Lewis Lanier suggest that thymocytes can develop along two mutually exclusive ontological pathways, giving rise to T cells that express either αß or γδ heterodimers, but not both or any other heterodimeric combination.

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References

Articles referenced by this article (25)

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Cited by: 58 articles | PMID: 9586633

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The T-cell antigen receptor gamma gene: rearrangement and cell lineages.

Affiliations

Authors

Authors

ORCIDs linked to this article

Abstract

Full text links

References

The molecular genetics of the T-cell antigen receptor and T-cell antigen recognition.

Structure, function, and serology of the T-cell antigen receptor complex.

Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences.

Structure, organization, and somatic rearrangement of T cell gamma genes.

Limited diversity of the rearranged T-cell gamma gene.

T cell-specific gamma genes in C57BL/10 mice. Sequence and expression of new constant and variable region genes.

Two tandemly organized human genes encoding the T-cell gamma constant-region sequences show multiple rearrangement in different T-cell types.

Developmental regulation of T-cell receptor gene expression.

Expression of T-cell antigen receptor genes during fetal development in the thymus.

Synchronized rearrangement of T-cell gamma and beta chain genes in fetal thymocyte development.

Citations & impact

Impact metrics

Citations of article over time

Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1016/0167-5699(87)90014-4

Article citations

Temporal predisposition to αβ and γδ T cell fates in the thymus.

Emerging role of gammadelta T-cells in health and disease.

Evidence that gammadelta versus alphabeta T cell fate determination is initiated independently of T cell receptor signaling.

Molecular determinants of TCR expression and selection.

The developmental fate of T cells is critically influenced by TCRgammadelta expression.

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The T-cell antigen receptor gamma gene: rearrangement and cell lineages.

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