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Brain metabolism assessed via proton magnetic resonance spectroscopy in patients with amnestic or vascular mild cognitive impairment.

Author information

Affiliations

  • 1. Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
      Authors
    • Zhu X 1
    • Sun Z 1
    (2 authors)
  • 2. Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China; Department of Neurology, Anhui No. 2 Provincial People's Hospital, Hefei, Anhui Province, China.
      Authors
    • Cao L 2
    (1 author)
  • 3. Department of Magnetic Resonance Room, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
      Authors
    • Hu X 3
    • Wang H 3
    • Liu F 3
    (3 authors)
  • 4. Department of Emergency, The Third Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
      Authors
    • Dong Y 4
    (1 author)

ORCIDs linked to this article

Clinical Neurology and Neurosurgery, 26 Dec 2014, 130:80-85
https://doi.org/10.1016/j.clineuro.2014.12.005 PMID: 25590663 

Abstract 

Background and objectives

To address the possible role of brain regional metabolic differences between different types of mild cognitive impairment (MCI).

Patients and methods

Brain regional metabolites in patients with amnestic mild cognitive impairment (A-MCI) and vascular mild cognitive impairment (V-MCI) were measured via proton magnetic resonance spectroscopy (1H MRS) technique. Twenty-eight patients with A-MCI, 24 patients with V-MCI and 34 normal controls (NC) were tested by a battery of neuropsychological screens. All the subjects underwent the single voxel 1H MRS with the regions of interest (ROIs) located in the left frontal lobe, left basal ganglia and left hippocampus.

Results

The A-MCI showed lower NAA/Cr ratio in the left hippocampus. There was a significant correlation between recent memory score and the NAA/Cr ratio. In V-MCI, NAA/Cr ratio in the left frontal lobe was positively correlated with the cognitive score evaluated with Cambridge Cognitive Examination-Chinese version (CAMCOG-C) and its subscores of orientation, praxi, language and language comprehension.

Conclusions

This study indicated that there are differences in metabolism related to brain regions between A-MCI and V-MCI, thus it may be concluded that 1H MRS may be a useful tool to differentiate A-MCI and V-MCI.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/j.clineuro.2014.12.005

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Funding 

Funders who supported this work.

National Basic Research Program of China (1)

Natural Science Foundation of Anhui Province (1)

Natural Science Foundation of Ministry of Education in Anhui Province (1)