Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Loeys-Dietz syndrome and pregnancy: The first ten years.

Author information

Affiliations

  • 1. Consultant Obstetric Physician, Oxford University Hospitals NHS Foundation Trust, UK.
      Authors
    • Frise CJ 1
    (1 author)
  • 2. Clinical Lecturer, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, UK.
      Authors
    • Pitcher A 2
    (1 author)
  • 3. Consultant Obstetric Physician, Oxford University Hospitals NHS Foundation Trust; Honorary Senior Clinical Lecturer, University of Oxford, UK.
      Authors
    • Mackillop L 3
    (1 author)

ORCIDs linked to this article

International Journal of Cardiology, 11 Oct 2016, 226:21-25
https://doi.org/10.1016/j.ijcard.2016.10.024 PMID: 27780078 

Review

Abstract 

The physiological and haemodynamic changes that occur in pregnancy and the postpartum period increase the risk of aortic dissection. Loeys-Dietz syndrome results from mutations in the genes encoding components of the TGF-β signalling pathway; aortic pathology is of particular concern in this condition but other vascular abnormalities can also be present. Significant maternal morbidity and mortality has been described in patients with Loeys-Dietz syndrome, but successful and uncomplicated pregnancies are still possible. Nevertheless, all patients with this condition should, at present, be treated as very high risk in pregnancy and the postpartum period, until reliable risk prediction tools become available. This review summarises the recent advances in the understanding of the pathophysiology of this condition, and the management strategies currently advocated.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/j.ijcard.2016.10.024

References 

Articles referenced by this article (35)

Show 10 more references (10 of 35)

Citations & impact 

Impact metrics

9
Citations
Jump to Citations

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/15121098
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/15121098

Smart citations by scite.ai
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1016/j.ijcard.2016.10.024

Supporting
Mentioning
Contrasting
1
26
0

Article citations

Go to all (9) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

Funding 

Funders who supported this work.

Academy of Medical Sciences (1)

British Heart Foundation (1)