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Association of Perinatal Risk Factors with Autism Spectrum Disorder.

Author information

Affiliations

  • 1. Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California.
      Authors
    • Getahun D 1
    • Xiang AH 1
    • Chiu V 1
    • Jacobsen SJ 1
    (4 authors)
  • 2. Division of Maternal-Fetal Medicine, Department of Obstetrics-Gynecology, Kaiser Permanente Southern California, West Los Angeles, Los Angeles.
      Authors
    • Fassett MJ 2
    (1 author)
  • 3. Winthrop University Hospital Research Institute, Winthrop University Hospital, Mineola, New York.
      Authors
    • Peltier MR 3
    (1 author)
  • 4. Department of Obstetrics-Gynecology, University of California, Irvine, California.
      Authors
    • Wing DA 4
    (1 author)

ORCIDs linked to this article

American Journal of Perinatology, 31 Jan 2017, 34(3):295-304
https://doi.org/10.1055/s-0036-1597624 PMID: 28099978 

Abstract 

Objective To examine the association between exposures to perinatal factors and autism spectrum disorders (ASD). Study Design A retrospective cohort study of ASD among children born in Kaiser Permanente Southern California hospitals between 1991 and 2009 (n = 594,638). Medical records were used to determine exposure to perinatal (antepartum and intrapartum) complications. ASD was diagnosed using DSM-IV criteria. Multivariable Cox regression was used to estimate hazard ratios (HRs). Result Children with ASD were more likely to be exposed to perinatal complications (HR = 1.15, 95% confidence interval [CI]: 1.09-1.21) than neurotypical children. Children exposed to antepartum (HR = 1.22, 95% CI: 1.10-1.36) and intrapartum (HR = 1.10, 95% CI: 1.04-1.17) complications were at increased risk of ASD. The risk was even greater when both antepartum and intrapartum conditions were present (HR = 1.44, 95% CI: 1.26-1.63). Conclusion Exposure to antepartum or intrapartum complications increases the risk of ASD in the offspring. Therefore, pregnancy complications may help identify children who could benefit from early screening and intervention for this common neurodevelopmental condition.

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Read article at publisher's site: https://doi.org/10.1055/s-0036-1597624

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