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The role of IL-7 in Immunity and Cancer.

Author information

Affiliations

  • 1. Department of Microbiology, Immunology and Pathology, Des Moines University, Des Moines, IA, U.S.A.
      Authors
    • Lin J 1
    • Xiao H 1
    • Ding VA 1
    • Fang Y 1, 2
    (4 authors)
  • 2. Department of Surgery, University of Missouri School of Medicine, Columbia, MO, U.S.A.
      Authors
    • Zhu Z 2
    • Wakefield MR 2
    • Bai Q 2
    • Fang Y 1, 2
    (4 authors)

ORCIDs linked to this article

Anticancer Research, 01 Mar 2017, 37(3):963-967
https://doi.org/10.21873/anticanres.11405 PMID: 28314253 

Review

Abstract 

Interleukin-7 (IL-7) is a cytokine that has been known since long in immunology, mainly regarding its effects on T-cells and B-cells. IL-7 has been demonstrated to be necessary for both B-cell and T-cell proliferation and lack of IL-7 causes immature immune cell arrest. Interestingly, in recent years, certain studies have strongly suggested that the role of IL-7 is far beyond the field of immunology, it might have direct or indirect effect on cancer. This review aims to summarize the role of IL-7 in immunity and its role in the pathogenesis of neoplasia.

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Read article at publisher's site: https://doi.org/10.21873/anticanres.11405

Read article for free, from open access legal sources, via Unpaywall: http://ar.iiarjournals.org/content/37/3/963.full.pdfUnpaywall

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