Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Abstract 


Taxol, a plant alkaloid stabilizer of microtubules, inhibits in vitro the replication of the human pathogenic flagellate Trichomonas vaginalis in a dose-dependent fashion. Micromolar concentrations of the drug induce massive assembly of microtubules, resistant to antimicrotubule agents, and block the mitosis of the protozoa at an early stage preceding the formation of the spindle fibers and the depolymerization of the axostylar microtubules. Some hypotheses involving the inactivation of the microtubule-organizing centers and the stabilization of axostylar microtubules are formulated to explain the mechanism of action of taxol.

References 


Articles referenced by this article (21)


Show 10 more references (10 of 21)

Citations & impact 


Impact metrics

Jump to Citations

Citations of article over time

Smart citations by scite.ai
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1111/j.1550-7408.1986.tb05602.x

Supporting
Mentioning
Contrasting
1
11
5

Article citations


Go to all (9) article citations