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Taxol, a microtubule stabilizing agent, blocks the replication of Trypanosoma cruzi.

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Proceedings of the National Academy of Sciences of the United States of America, 01 Jul 1981, 78(7):4571-4575
https://doi.org/10.1073/pnas.78.7.4571 PMID: 6117077 PMCID: PMC319834

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Abstract 

Taxol, an experimental antitumor agent and stabilizer of microtubules, inhibits in vitro replication of the human pathogenic hemoflagellate Trypanosoma cruzi. Micromolar concentrations of the drug prevent the completion of cell division in these organisms but allow the multiplication of cell organelles such as the nucleus, kinetoplast, and flagellum. The result is the formation of motile organisms that have extra organelles but cannot fully replicate. Division proceeds to a relatively fixed locus on the long axis of the organism, suggesting the presence of a specific affected structure or function at this site. It is postulated that taxol produces these effects by stabilizing a portion of the microtubular cytoskeleton of T. cruzi.

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Proc Natl Acad Sci U S A. 1981 Jul; 78(7): 4571–4575.
PMCID: PMC319834
PMID: 6117077

Taxol, a microtubule stabilizing agent, blocks the replication of Trypanosoma cruzi.

S G Baum, M Wittner, J P Nadler, S B Horwitz, J E Dennis, P B Schiff, and H B Tanowitz
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Abstract

Taxol, an experimental antitumor agent and stabilizer of microtubules, inhibits in vitro replication of the human pathogenic hemoflagellate Trypanosoma cruzi. Micromolar concentrations of the drug prevent the completion of cell division in these organisms but allow the multiplication of cell organelles such as the nucleus, kinetoplast, and flagellum. The result is the formation of motile organisms that have extra organelles but cannot fully replicate. Division proceeds to a relatively fixed locus on the long axis of the organism, suggesting the presence of a specific affected structure or function at this site. It is postulated that taxol produces these effects by stabilizing a portion of the microtubular cytoskeleton of T. cruzi.

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Selected References

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  • Wani MC, Taylor HL, Wall ME, Coggon P, McPhail AT. Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc. 1971 May 5;93(9):2325–2327. [Abstract] [Google Scholar]
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