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Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization.

Nucleic Acids Research, 01 Sep 1985, 13(17):6361-6373
https://doi.org/10.1093/nar/13.17.6361 PMID: 2995927 PMCID: PMC321958

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Abstract 

Human Tumor Necrosis Factor and Lymphotoxin are cytotoxic proteins which have similar biological activities and share 30 percent amino acid homology. The single copy genes which encode these proteins share several structural features: each gene is approximately three kilobase pairs in length and is interrupted by three introns. In addition, these genes are closely linked and have been mapped to human chromosome 6. However, only the last exons of both genes, which code for more than 80 percent of each secreted protein, are significantly homologous (56 percent).

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Nucleic Acids Res. 1985 Sep 11; 13(17): 6361–6373.
PMCID: PMC321958
PMID: 2995927

Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization.

G E Nedwin, S L Naylor, A Y Sakaguchi, D Smith, J Jarrett-Nedwin, D Pennica, D V Goeddel, and P W Gray
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Abstract

Human Tumor Necrosis Factor and Lymphotoxin are cytotoxic proteins which have similar biological activities and share 30 percent amino acid homology. The single copy genes which encode these proteins share several structural features: each gene is approximately three kilobase pairs in length and is interrupted by three introns. In addition, these genes are closely linked and have been mapped to human chromosome 6. However, only the last exons of both genes, which code for more than 80 percent of each secreted protein, are significantly homologous (56 percent).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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