Cellular functions of long noncoding RNAs.

Yao RW; Wang Y; Chen LL

doi:10.1038/s41556-019-0311-8

Cellular functions of long noncoding RNAs.

Yao RW ¹,

Wang Y ¹,

Chen LL ¹

Affiliations

1. State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Authors
Yao RW¹
Wang Y¹
Chen LL¹
(3 authors)

ORCIDs linked to this article

Nature Cell Biology, 02 May 2019, 21(5):542-551
https://doi.org/10.1038/s41556-019-0311-8 PMID: 31048766

Review

Abstract

A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential, are transcribed from the mammalian genome. They are emerging as important regulators in gene expression networks by controlling nuclear architecture and transcription in the nucleus and by modulating mRNA stability, translation and post-translational modifications in the cytoplasm. In this Review, we highlight recent progress in cellular functions of lncRNAs at the molecular level in mammalian cells.

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References

Articles referenced by this article (136)

Schematic modelling of peripheral astigmatism in real eyes.
Dunne MC, Barnes DA
Ophthalmic Physiol Opt, (3):235-239 1987
MED: 3684276
The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression.
Derrien T, Johnson R, Bussotti G, Tanzer A, Djebali S, Tilgner H, Guernec G, Martin D, Merkel A, Knowles DG, Lagarde J, Veeravalli L, Ruan X, Ruan Y, Lassmann T, Carninci P, Brown JB, Lipovich L, Gonzalez JM, [...] Guigo R
Genome Res, (9):1775-1789 2012
MED: 22955988
3' end processing of a long nuclear-retained noncoding RNA yields a tRNA-like cytoplasmic RNA.
Wilusz JE, Freier SM, Spector DL
Cell, (5):919-932 2008
MED: 19041754
MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles.
Sunwoo H, Dinger ME, Wilusz JE, Amaral PP, Mattick JS, Spector DL
Genome Res, (3):347-359 2008
MED: 19106332
Long noncoding RNAs with snoRNA ends.
Yin QF, Yang L, Zhang Y, Xiang JF, Wu YW, Carmichael GG, Chen LL
Mol Cell, (2):219-230 2012
MED: 22959273
Unusual Processing Generates SPA LncRNAs that Sequester Multiple RNA Binding Proteins.
Wu H, Yin QF, Luo Z, Yao RW, Zheng CC, Zhang J, Xiang JF, Yang L, Chen LL
Mol Cell, (3):534-548 2016
MED: 27871485
SLERT Regulates DDX21 Rings Associated with Pol I Transcription.
Xing YH, Yao RW, Zhang Y, Guo CJ, Jiang S, Xu G, Dong R, Yang L, Chen LL
Cell, (4):664-678.e16 2017
MED: 28475895
Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types.
Salzman J, Gawad C, Wang PL, Lacayo N, Brown PO
PLoS One, (2):e30733 2012
MED: 22319583
Circular RNAs are a large class of animal RNAs with regulatory potency.
Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, Loewer A, Ziebold U, Landthaler M, Kocks C, le Noble F, Rajewsky N
Nature, (7441):333-338 2013
MED: 23446348
Circular intronic long noncoding RNAs.
Zhang Y, Zhang XO, Chen T, Xiang JF, Yin QF, Xing YH, Zhu S, Yang L, Chen LL
Mol Cell, (6):792-806 2013
MED: 24035497

Show 10 more references (10 of 136)

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Search life-sciences literature (45,103,589 articles, preprints and more)

Cellular functions of long noncoding RNAs.

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ORCIDs linked to this article

Abstract

Full text links

References

Schematic modelling of peripheral astigmatism in real eyes.

The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression.

3' end processing of a long nuclear-retained noncoding RNA yields a tRNA-like cytoplasmic RNA.

MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles.

Long noncoding RNAs with snoRNA ends.

Unusual Processing Generates SPA LncRNAs that Sequester Multiple RNA Binding Proteins.

SLERT Regulates DDX21 Rings Associated with Pol I Transcription.

Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types.

Circular RNAs are a large class of animal RNAs with regulatory potency.

Circular intronic long noncoding RNAs.

Citations & impact

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Citations of article over time

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Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1038/s41556-019-0311-8

Article citations

Deciphering the roles of cellular and extracellular non-coding RNAs in chemotherapy-induced cardiotoxicity.

A review of current developments in RNA modifications in lung cancer.

ER stress-induced LINC00173 promotes the apoptosis of ovarian granulosa cells by regulating the HRK/PI3K/AKT pathway in polycystic ovary syndrome.

A novel arginine methylation-associated lncRNA signature effectively predicts prognosis in breast cancer patients.

Long Noncoding RNAs Expressed in Mouse Pituitary Development and Mature Hormone-Producing Cells.

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Cellular functions of long noncoding RNAs.

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