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Proliferation and differentiation of rat neuroepithelial precursor cells in vivo.

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  • 1. Departments of Biology and Brain Science, Whitaker College, Massachusetts Institute of Technology, Cambridge 02139.
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    • Frederiksen K 1
    (1 author)

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 01 Apr 1988, 8(4):1144-1151
https://doi.org/10.1523/jneurosci.08-04-01144.1988 PMID: 3357014 PMCID: PMC6569254

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Abstract 

Important features of adult neuronal number, location, and type are a consequence of early embryonic events that occur before neurons have differentiated. We have measured cell number during embryogenesis of the rat CNS. Markers that are expressed in the proliferating neuronal precursor are required to study the mechanisms controlling their proliferation and differentiation. By applying immunohistochemistry, fluorescence-activated cell sorting, and 3H-thymidine auto-radiography to dissociated rat CNS cells, we show that the monoclonal antibody Rat 401 recognizes a cell population with proliferative, temporal, and quantitative features expected of neuronal precursors.

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Logo of jneurosciThis ArticleAbout the JournalFor AuthorsSign up for AlertsThe Journal of NeuroscienceSociety for Neuroscience
J Neurosci. 1988 Apr 1; 8(4): 1144–1151.
PMCID: PMC6569254
PMID: 3357014

Proliferation and differentiation of rat neuroepithelial precursor cells in vivo

K Frederiksen and RD McKay
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Abstract

Important features of adult neuronal number, location, and type are a consequence of early embryonic events that occur before neurons have differentiated. We have measured cell number during embryogenesis of the rat CNS. Markers that are expressed in the proliferating neuronal precursor are required to study the mechanisms controlling their proliferation and differentiation. By applying immunohistochemistry, fluorescence-activated cell sorting, and 3H-thymidine auto-radiography to dissociated rat CNS cells, we show that the monoclonal antibody Rat 401 recognizes a cell population with proliferative, temporal, and quantitative features expected of neuronal precursors.

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