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Changes in signalling from faecal neuroactive metabolites following dietary modulation of IBS pain.

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Author information

Affiliations

  • 1. Department of Sport, Exercise and Nutrition Sciences, La Trobe University, Melbourne, Victoria, Australia.
      Authors
    • Tuck CJ 1, 2
    (1 author)
  • 2. Gastrointestinal Diseases Research Unit, Queen's University, Kingston, Ontario, Canada.
      Authors
    • Tuck CJ 1, 2
    • Abu Omar A 2
    • Osman S 2
    • Jiménez-Vargas NN 2
    • Yu Y 2
    • Bennet SM 2
    • Lopez-Lopez C 2
    • Jaramillo-Polanco JO 2
    • Baker CC 2
    • Bennett AS 2
    • Guzman-Rodriguez M 2
    • Tsang Q 2
    • Alward T 2
    • Morissette C 2
    • Vanner SJ 2
    • Lomax AE 2
    (16 authors)
  • 3. Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
      Authors
    • De Palma G 3
    • Verdu EF 3
    • Bercik P 3
    (3 authors)
  • 4. Department of Medicine, Hopital Maisonneuve-Rosemont, Montreal, Québec, Canada.
      Authors
    • Rolland S 4
    (1 author)
  • 5. Gastrointestinal Diseases Research Unit, Queen's University, Kingston, Ontario, Canada
      Authors
    • Reed DE 5
    (1 author)

ORCIDs linked to this article

Show all (10)

Gut, 13 Dec 2022, :gutjnl-2022-327260
https://doi.org/10.1136/gutjnl-2022-327260 PMID: 36591617 

A comment on this article appears in "Neuroactive changes in the bowel of patients with IBS on low FODMAP diet: another piece of the puzzle." Gut. 2023 Sep;72(9):1636-1637.

Abstract 

Objective

Dietary therapies for irritable bowel syndrome (IBS) have received increasing interest but predicting which patients will benefit remains a challenge due to a lack of mechanistic insight. We recently found evidence of a role for the microbiota in dietary modulation of pain signalling in a humanised mouse model of IBS. This randomised cross-over study aimed to test the hypothesis that pain relief following reduced consumption of fermentable carbohydrates is the result of changes in luminal neuroactive metabolites.

Design

IBS (Rome IV) participants underwent four trial periods: two non-intervention periods, followed by a diet low (LFD) and high in fermentable carbohydrates for 3 weeks each. At the end of each period, participants completed questionnaires and provided stool. The effects of faecal supernatants (FS) collected before (IBS FS) and after a LFD (LFD FS) on nociceptive afferent neurons were assessed in mice using patch-clamp and ex vivo colonic afferent nerve recording techniques.

Results

Total IBS symptom severity score and abdominal pain were reduced by the LFD (N=25; p<0.01). Excitability of neurons was increased in response to IBS FS, but this effect was reduced (p<0.01) with LFD FS from pain-responders. IBS FS from pain-responders increased mechanosensitivity of nociceptive afferent nerve axons (p<0.001), an effect lost following LFD FS administration (p=NS) or when IBS FS was administered in the presence of antagonists of histamine receptors or protease inhibitors.

Conclusions

In a subset of IBS patients with improvement in abdominal pain following a LFD, there is a decrease in pronociceptive signalling from FS, suggesting that changes in luminal mediators may contribute to symptom response.

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Read article at publisher's site: https://doi.org/10.1136/gutjnl-2022-327260

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Funding 

Funders who supported this work.

Allergan Foundation (1)

American Gastroenterological Association (1)

Canadian Institutes of Health Research (1)

Canadian Nutrition Society (1)

Nestle (1)

Weston Family Microbiota Initiative (1)