Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Acute paracetamol poisoning.

British Medical Journal, 01 Sep 1970, 3(5722):557-558
https://doi.org/10.1136/bmj.3.5722.557 PMID: 5311516 PMCID: PMC1701561

Free full text in Europe PMC

Abstract 

Of 41 cases of acute paracetamol poisoning one died of gastrointestinal haemorrhage and acute massive necrosis of the liver, three became jaundiced, and 13 others had biochemical evidence of hepatocellular damage. Liver damage is a toxic effect which is present in most patients who ingest more than 15 g. of paracetamol. One patient with liver damage survived renal failure due to acute tubular necrosis. It is suggested that the renal lesion was also the result of paracetamol overdosage.Profound hypoglycaemia and metabolic acidosis may also complicate severe poisoning. Plasma levels of para-aminophenol fall rapidly, and procedures currently used to enhance the elimination of the drug cannot be expected to prevent development of hepatic damage.

Free full text 

Logo of brmedjLink to Publisher's site
Br Med J. 1970 Sep 5; 3(5722): 557–558.
PMCID: PMC1701561
PMID: 5311516

Acute Paracetamol Poisoning

A. T. Proudfoot and N. Wright
Copyright and License information Disclaimer

Abstract

Of 41 cases of acute paracetamol poisoning one died of gastrointestinal haemorrhage and acute massive necrosis of the liver, three became jaundiced, and 13 others had biochemical evidence of hepatocellular damage. Liver damage is a toxic effect which is present in most patients who ingest more than 15 g. of paracetamol. One patient with liver damage survived renal failure due to acute tubular necrosis. It is suggested that the renal lesion was also the result of paracetamol overdosage.

Profound hypoglycaemia and metabolic acidosis may also complicate severe poisoning. Plasma levels of para-aminophenol fall rapidly, and procedures currently used to enhance the elimination of the drug cannot be expected to prevent development of hepatic damage.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (431K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.
 
icon of scanned page 557
557
icon of scanned page 558
558
 

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Davidson DG, Eastham WN. Acute liver necrosis following overdose of paracetamol. Br Med J. 1966 Aug 27;2(5512):497–499. [Europe PMC free article] [Abstract] [Google Scholar]
  • JUDAH JD. Effect of antihistamines on mitochondrial swelling and liver injury. Nature. 1960 Feb 6;185:390–391. [Abstract] [Google Scholar]
  • Maclean D, Peters TJ, Brown RA, McCathie M, Baines GF, Robertson PG. Treatment of acute paracetamol poisoning. Lancet. 1968 Oct 19;2(7573):849–852. [Abstract] [Google Scholar]
  • Pimstone BL, Uys CJ. Liver necrosis and myocardiopathy following paracetamol overdosage. S Afr Med J. 1968 Mar 16;42(11):259–262. [Abstract] [Google Scholar]
  • Rose PG. Paracetamol overdose and liver damage. Br Med J. 1969 Feb 8;1(5640):381–382. [Europe PMC free article] [Abstract] [Google Scholar]
  • Thomson JS, Prescott LF. Liver damage and impaired glucose tolerance after paracetamol overdosage. Br Med J. 1966 Aug 27;2(5512):506–507. [Europe PMC free article] [Abstract] [Google Scholar]
  • Toghill PJ, Williams R, Stephens JD, Carroll JD. Acute hepatic necrosis following an overdose of paracetamol. Gastroenterology. 1969 Apr;56(4):773–776. [Abstract] [Google Scholar]
Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

Full text links 

Read article at publisher's site: https://doi.org/10.1136/bmj.3.5722.557

Read article for free, from open access legal sources, via Unpaywall: https://www.bmj.com/content/3/5722/557.full.pdfUnpaywall

Citations & impact 

Impact metrics

108
Citations
Jump to Citations

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/92993821
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/92993821

Smart citations by scite.ai
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1136/bmj.3.5722.557

Supporting
Mentioning
Contrasting
0
47
0

Article citations

Go to all (108) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.