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Inhibition of interjacent ribonucleic acid (26S) synthesis in cells infected by Sindbis virus.

Journal of Virology, 01 Aug 1969, 4(2):117-122
https://doi.org/10.1128/jvi.4.2.117-122.1969 PMID: 5817400 PMCID: PMC375845

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Abstract 

The interrelationship of viral ribonucleic acid (RNA) and protein synthesis in cells infected by Sindbis virus was investigated. When cultures were treated with puromycin early in the course of infection, the synthesis of interjacent RNA (26S) was preferentially inhibited. A similar result was obtained by shifting cells infected by one temperature-sensitive mutant defective in RNA synthesis from the permissive (29 C) to the nonpermissive (41.5 C) temperature. Under both conditions, the viral RNA produced appeared to be fully active biologically. Once underway, the synthesis of viral RNA in wild-type Sindbis infections did not require concomitant protein synthesis.

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J Virol. 1969 Aug; 4(2): 117–122.
PMCID: PMC375845
PMID: 5817400

Inhibition of Interjacent Ribonucleic Acid (26S) Synthesis in Cells Infected by Sindbis Virus

Christina M. Scheele and E. R. Pfefferkorn
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Abstract

The interrelationship of viral ribonucleic acid (RNA) and protein synthesis in cells infected by Sindbis virus was investigated. When cultures were treated with puromycin early in the course of infection, the synthesis of interjacent RNA (26S) was preferentially inhibited. A similar result was obtained by shifting cells infected by one temperature-sensitive mutant defective in RNA synthesis from the permissive (29 C) to the nonpermissive (41.5 C) temperature. Under both conditions, the viral RNA produced appeared to be fully active biologically. Once underway, the synthesis of viral RNA in wild-type Sindbis infections did not require concomitant protein synthesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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