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Enzyme-catalysed conjugations of glutathione with unsaturated compounds.

The Biochemical Journal, 01 Jul 1967, 104(1):95-102
https://doi.org/10.1042/bj1040095 PMID: 6035529 PMCID: PMC1270549

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Abstract 

1. Rat-liver supernatant catalyses the reaction of diethyl maleate with glutathione. 2. Evidence is presented that the enzyme involved is different from the known glutathione-conjugating enzymes, glutathione S-alkyltransferase, S-aryltransferase and S-epoxidetransferase. 3. Rat-liver supernatant catalyses the reaction of a number of other alphabeta-unsaturated compounds, including aldehydes, ketones, lactones, nitriles and nitro compounds, with glutathione: separate enzymes may be responsible for these reactions.

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Biochem J. 1967 Jul; 104(1): 95–102.
PMCID: PMC1270549
PMID: 6035529

Enzyme-catalysed conjugations of glutathione with unsaturated compounds

E. Boyland and L. F. Chasseaud
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Abstract

1. Rat-liver supernatant catalyses the reaction of diethyl maleate with glutathione. 2. Evidence is presented that the enzyme involved is different from the known glutathione-conjugating enzymes, glutathione S-alkyltransferase, S-aryltransferase and S-epoxidetransferase. 3. Rat-liver supernatant catalyses the reaction of a number of other αβ-unsaturated compounds, including aldehydes, ketones, lactones, nitriles and nitro compounds, with glutathione: separate enzymes may be responsible for these reactions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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