Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Genetic mapping of the human X chromosome by using restriction fragment length polymorphisms.

Proceedings of the National Academy of Sciences of the United States of America, 01 May 1984, 81(9):2836-2839
https://doi.org/10.1073/pnas.81.9.2836 PMID: 6326147 PMCID: PMC345165

Free full text in Europe PMC

Abstract 

Using a human X chromosome-specific DNA library, we have found arbitrary single-copy DNA sequences that reveal useful restriction fragment length polymorphisms. The inheritance of these and other available polymorphic DNA markers has been studied in a series of unrelated three-generation families with large sibships. These families reveal parental phase and allow determination of recombination frequencies by counting recombinant and nonrecombinant chromosomes. The resulting genetic map indicates that the minimal distance from Xp22 to Xqter is 215 recombination units. The spacing of the marker loci is such that the majority of the loci on the X chromosome, including disease loci, will lie within 20 centimorgans of at least one of these loci.

Free full text 

Logo of pnasLink to Publisher's site
Proc Natl Acad Sci U S A. 1984 May; 81(9): 2836–2839.
PMCID: PMC345165
PMID: 6326147

Genetic mapping of the human X chromosome by using restriction fragment length polymorphisms.

D Drayna, K Davies, D Hartley, J L Mandel, G Camerino, R Williamson, and R White
Copyright and License information Disclaimer

Abstract

Using a human X chromosome-specific DNA library, we have found arbitrary single-copy DNA sequences that reveal useful restriction fragment length polymorphisms. The inheritance of these and other available polymorphic DNA markers has been studied in a series of unrelated three-generation families with large sibships. These families reveal parental phase and allow determination of recombination frequencies by counting recombinant and nonrecombinant chromosomes. The resulting genetic map indicates that the minimal distance from Xp22 to Xqter is 215 recombination units. The spacing of the marker loci is such that the majority of the loci on the X chromosome, including disease loci, will lie within 20 centimorgans of at least one of these loci.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (826K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.
 
icon of scanned page 2836
2836
icon of scanned page 2837
2837
icon of scanned page 2838
2838
icon of scanned page 2839
2839
 

Images in this article

Image
Image
on p.2837
Image
Image
on p.2837
Image
Image
on p.2837
Image
Image
on p.2838
Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Kan YW, Dozy AM. Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation. Proc Natl Acad Sci U S A. 1978 Nov;75(11):5631–5635. [Europe PMC free article] [Abstract] [Google Scholar]
  • Botstein D, White RL, Skolnick M, Davis RW. Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet. 1980 May;32(3):314–331. [Europe PMC free article] [Abstract] [Google Scholar]
  • Denaro M, Blanc H, Johnson MJ, Chen KH, Wilmsen E, Cavalli-Sforza LL, Wallace DC. Ethnic variation in Hpa 1 endonuclease cleavage patterns of human mitochondrial DNA. Proc Natl Acad Sci U S A. 1981 Sep;78(9):5768–5772. [Europe PMC free article] [Abstract] [Google Scholar]
  • Davies KE, Pearson PL, Harper PS, Murray JM, O'Brien T, Sarfarazi M, Williamson R. Linkage analysis of two cloned DNA sequences flanking the Duchenne muscular dystrophy locus on the short arm of the human X chromosome. Nucleic Acids Res. 1983 Apr 25;11(8):2303–2312. [Europe PMC free article] [Abstract] [Google Scholar]
  • Antonarakis SE, Phillips JA, 3rd, Mallonee RL, Kazazian HH, Jr, Fearon ER, Waber PG, Kronenberg HM, Ullrich A, Meyers DA. Beta-globin locus is linked to the parathyroid hormone (PTH) locus and lies between the insulin and PTH loci in man. Proc Natl Acad Sci U S A. 1983 Nov;80(21):6615–6619. [Europe PMC free article] [Abstract] [Google Scholar]
  • Davies KE, Young BD, Elles RG, Hill ME, Williamson R. Cloning of a representative genomic library of the human X chromosome after sorting by flow cytometry. Nature. 1981 Oct 1;293(5831):374–376. [Abstract] [Google Scholar]
  • Kunkel LM, Tantravahi U, Eisenhard M, Latt SA. Regional localization on the human X of DNA segments cloned from flow sorted chromosomes. Nucleic Acids Res. 1982 Mar 11;10(5):1557–1578. [Europe PMC free article] [Abstract] [Google Scholar]
  • Southern EM. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol. 1975 Nov 5;98(3):503–517. [Abstract] [Google Scholar]
  • Dretzen G, Bellard M, Sassone-Corsi P, Chambon P. A reliable method for the recovery of DNA fragments from agarose and acrylamide gels. Anal Biochem. 1981 Apr;112(2):295–298. [Abstract] [Google Scholar]
  • Rigby PW, Dieckmann M, Rhodes C, Berg P. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. J Mol Biol. 1977 Jun 15;113(1):237–251. [Abstract] [Google Scholar]
  • Murray JM, Davies KE, Harper PS, Meredith L, Mueller CR, Williamson R. Linkage relationship of a cloned DNA sequence on the short arm of the X chromosome to Duchenne muscular dystrophy. Nature. 1982 Nov 4;300(5887):69–71. [Abstract] [Google Scholar]
  • Page D, de Martinville B, Barker D, Wyman A, White R, Francke U, Botstein D. Single-copy sequence hybridizes to polymorphic and homologous loci on human X and Y chromosomes. Proc Natl Acad Sci U S A. 1982 Sep;79(17):5352–5356. [Europe PMC free article] [Abstract] [Google Scholar]
  • Nussbaum RL, Crowder WE, Nyhan WL, Caskey CT. A three-allele restriction-fragment-length polymorphism at the hypoxanthine phosphoribosyltransferase locus in man. Proc Natl Acad Sci U S A. 1983 Jul;80(13):4035–4039. [Europe PMC free article] [Abstract] [Google Scholar]
  • Camerino G, Mattei MG, Mattei JF, Jaye M, Mandel JL. Close linkage of fragile X-mental retardation syndrome to haemophilia B and transmission through a normal male. Nature. 1983 Dec 15;306(5944):701–704. [Abstract] [Google Scholar]
  • Wolski KP, Schmid FR, Mittal KK. Genetic linkage between the HL-A system and a deficit of the second component (C2) of complement. Science. 1975 Jun 6;188(4192):1020–1022. [Abstract] [Google Scholar]
  • Chance PF, Dyer KA, Kurachi K, Yoshitake S, Ropers HH, Wieacker P, Gartler SM. Regional localization of the human factor IX gene by molecular hybridization. Hum Genet. 1983;65(2):207–208. [Abstract] [Google Scholar]
  • Wieacker P, Wienker TF, Dallapiccola B, Bender K, Davies KE, Ropers HH. Linkage relationships between Retinoschisis, Xg, and a cloned DNA sequence from the distal short arm of the X chromosome. Hum Genet. 1983;64(2):143–145. [Abstract] [Google Scholar]
Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

Full text links 

Read article at publisher's site: https://doi.org/10.1073/pnas.81.9.2836

Read article for free, from open access legal sources, via Unpaywall: https://europepmc.org/articles/pmc345165?pdf=renderUnpaywall

Citations & impact 

Impact metrics

128
Citations
Jump to Citations
1
Data citation
Jump to Data

Citations of article over time

Smart citations by scite.ai
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1073/pnas.81.9.2836

Supporting
Mentioning
Contrasting
2
33
0

Article citations

Go to all (128) article citations

Data 

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

Funding 

Funders who supported this work.

NIGMS NIH HHS (1)