A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response.

Cox JS; Walter P

doi:10.1016/s0092-8674(00)81360-4

A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response.

Cox JS ¹,

Walter P

Affiliations

1. Department of Biochemistry and Biophysics, University of California, School of Medicine, San Francisco 94143-0448, USA.
Authors
Cox JS¹
(1 author)

Cell, 01 Nov 1996, 87(3):391-404
https://doi.org/10.1016/s0092-8674(00)81360-4 PMID: 8898193

A comment on this article appears in "An elegant UPR discovery." Nat Rev Mol Cell Biol. 2018 Sep;19(9):545. A comment on this article appears in "Mixed mechanisms in yeast pre-mRNA splicing?" Cell. 1996 Nov 1;87(3):357-9.

Abstract

Cells respond to an accumulation of unfolded proteins in the endoplasmic reticulum (ER) by increasing transcription of genes encoding ER-resident proteins. The information is transmitted from the ER lumen to the nucleus by an intracellular signaling pathway, the unfolded protein response (UPR). We have identified a basic-leucine zipper transcription factor, Hac1p, that is required for the UPR and binds to the UPR element in the promoter of UPR-regulated genes. Surprisingly, Hac1p is found in UPR-activated cells only, and its level is controlled by regulated splicing of its mRNA. Splicing replaces the C-terminal tail of Hac1p with a different peptide that renders Hac1p more resistant to an otherwise extremely rapid ubiquitin-dependent degradation. We propose that the complex regulation of Hac1p expression serves to provide multiple levels at which the UPR can be controlled.

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References

Articles referenced by this article (36)

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Gene Ontology Annotation Project

https://www.ebi.ac.uk/QuickGO/annotations?reference=8898193

Proteins in UniProt (2)

Serine/threonine-protein kinase/endoribonuclease IRE1(UniProt - P32361)
Transcriptional activator HAC1(UniProt - P41546)

GlyGen is an international glycobioinformatics knowledgebase funded by The National Institutes of Health to facilitate glycoscience research by integrating diverse kinds of information, including glycomics, genomics, proteomics (and glycoproteomics), cell biology, developmental biology and biochemistry.

https://www.glygen.org/publication/MED/8898193

Saccharomyces Genome Database

https://www.yeastgenome.org/reference/S000045375

Search life-sciences literature (45,103,589 articles, preprints and more)

A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response.

Affiliations

Authors

Abstract

Full text links

References

A mutation allowing an mRNA secondary structure diminishes translation of Saccharomyces cerevisiae iso-1-cytochrome c.

The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest.

Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase.

Characterization of a transcriptional control element involved in proliferation of peroxisomes in yeast in response to oleate.

A simple and efficient procedure for transformation of yeasts.

Meiosis-specific RNA splicing in yeast.

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

Protein folding in the cell.

Title not supplied

Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant.

Citations & impact

Impact metrics

Citations of article over time

Alternative metrics

Smart citations by scite.ai
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1016/s0092-8674(00)81360-4

Article citations

Enhancement of Triple-Negative Breast Cancer-Specific Induction of Cell Death by Silver Nanoparticles by Combined Treatment with Proteotoxic Stress Response Inhibitors.

Disordered regions in the IRE1α ER lumenal domain mediate its stress-induced clustering.

Swi/Snf chromatin remodeling regulates transcriptional interference and gene repression.

Dysregulation of ceramide metabolism causes phytoceramide-dependent induction of the unfolded protein response.

Programmed cell death regulator BAP2 is required for IRE1-mediated unfolded protein response in Arabidopsis.

Data

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Gene Ontology Annotation Project

Proteins in UniProt (2)

Saccharomyces Genome Database

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Search life-sciences literature (45,103,589 articles, preprints and more)

A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response.

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Abstract

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Title not supplied

Citations & impact

Impact metrics

Citations of article over time

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Article citations

Data

Data that cites the article

Gene Ontology Annotation Project

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