| PMC full text: | Published online 2024 Apr 24. doi: 10.1093/infdis/jiae198
|
Table 2.
Likelihood of Recovery or Death Based on Baseline Viral Load or Inflammatory Biomarker
| Recovery | Mortality | |||||
|---|---|---|---|---|---|---|
| Disease Severity: Biomarker | RRR | 95% CI | P Value | HR | 95% CI | P Value |
| Moderate/severe | ||||||
| Nucleocapsid, log10 pg/mL | 0.53 | .42–.66 | <.001 | 3.92 | 1.11–13.86 | .034 |
| RNA, log10 copies/mL | ||||||
 Plasma | 0.41 | .33–.53 | <.001 | 4.44 | 1.41–13.96 | .011 |
|
Upper respiratory | 0.50 | .40–.64 | <.001 | 7.80 | 1.70–35.82 | .008 |
| Inflammatory Biomarkers, log10 pg/mL | ||||||
|
CRP | 0.83 | .67–1.04 | .106 | 1.79 | .65–4.95 | .259 |
|
IL-6 | 0.53 | .42–.67 | <.001 | 3.68 | 1.32–10.29 | .013 |
| Critical | ||||||
| Nucleocapsid, log10 pg/mL | 0.77 | .58–1.03 | .078 | 1.07 | .61–1.87 | .805 |
| RNA, log10 copies/mL | ||||||
|
Plasma | 0.58 | .44–.78 | <.001 | 1.53 | .83–2.85 | .175 |
|
Upper respiratory | 0.84 | .63–1.12 | .239 | 1.12 | .64–1.98 | .687 |
| Inflammatory Biomarkers, log10 pg/mL | ||||||
|
CRP | 0.74 | .55–1.00 | .050 | 1.75 | .93–3.29 | .085 |
|
IL-6 | 0.39 | .28–.53 | <.001 | 3.55 | 1.41–8.96 | .007 |
Cox model estimates of HR for mortality and RRR based on baseline elevation of viral load or inflammatory biomarker (dichotomized at baseline median) when adjusted for treatment arm.
Abbreviations: CRP, C-reactive protein; HR, hazard ratio; IL-6, interleukin 6; RRR, recovery rate ratio