Efficacy and Safety of Hepatic Arterial Infusion Chemotherapy(HAIC) Combined with PD-1 Inhibitors for Advanced Hepatocellular Carcinoma with Macrovascular Invasion: A Multicenter Propensity Score Matching Analysis

doi:10.2147/JHC.S483824

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J Hepatocell Carcinoma. 2024; 11: 1961–1978.

Published online 2024 Oct 16. doi: 10.2147/JHC.S483824

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Table 3

Best Tumor Response Before and After the Adjustment of PSM in the Overall Group and Subgroup

	Before PSM			After PSM
	HAICPD1 group	HAIC group	P value	HAICPD1 group	HAIC group	P value
Overall	(n=173)	(n=316)		(n=167)	(n=167)
Best Response			< 0.0001			< 0.0001
CR	1(0.5)	2(0.6)		1(0.6)	1(0.6)
PR	79(45.7)	64 (20.3)		73(43.7)	33(19.8)
SD	76 (31.9)	194(61.4)		76(45.5)	103(61.7)
PD	17(9.8)	56(17.7)		17(10.2)	30(18.0)
ORR	46.2%(80/173)	20.9%(66/316)	< 0.0001	44.3%(74/167)	20.4%(34/167)	< 0.0001
DCR	90.2%(156/173)	82.3%(260/316)	0.019	89.8%(150/167)	82.0%(137/167)	0.041
Subgroup
Metastasis(-)	n=102	n=184	< 0.0001	n=98	n=113	< 0.0001
CR	1(1.0)	1(0.5)		1(1.0)	0(0.0)
PR	58(56.9)	47(25.5)		54(55.1)	28(24.8)
SD	36(35.3)	104(56.5)		36(36.7)	66(58.4)
PD	7(6.9)	32(17.4)		7(7.1)	19(16.8)
ORR	57.8(59/102)	(48/184)	< 0.0001	56.1(55/98)	24.8(28/113)	< 0.0001
DCR	93.1(95/102)	(152/184)	0.013	87.8(86/98)	80.6(79/98)	0.017
Metastasis(+)	n=71	n=132	< 0.0001	n=69	n=54	< 0.0001
CR	0(0.0)	1(0.8)		0(0.0)	1(1.9)
PR	21(29.6)	17(12.9)		19(27.5)	5(9.3)
SD	40(56.3)	90(68.2)		40(58.0)	37(68.5)
PD	10(14.1)	24(18.2)		10(14.5)	11(20.4)
ORR	29.6(21/71)	13.6(18/132)	< 0.0001	27.5(19/69)	11.1(6/54)	< 0.0001
DCR	85.9(61/71)	81.8(108/132)	0.456	85.5(59/69)	79.6(43/54)	0.390

Note: Data are presented as n (%).

Abbreviations: PSM, Propensity Score Matching; HAIC, Hepatic artery infusion chemotherapy; HAICPD1, Hepatic artery infusion chemotherapy plus PD1 inhibitors; CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease; ORR, objective response rate; DCR, disease control rate.