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Competition between adjacent meiotic recombination hotspots in the yeast Saccharomyces cerevisiae.

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  • 1. Department of Biology, University of North Carolina, Chapel Hill 27599-3280, USA.
      Authors
    • Fan QQ 1
    (1 author)

Genetics, 01 Mar 1997, 145(3):661-670
https://doi.org/10.1093/genetics/145.3.661 PMID: 9055076 PMCID: PMC1207851

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Abstract 

In a wild-type strain of Saccharomyces cerevisiae, a hotspot for meiotic recombination is located upstream of the HIS4 gene. An insertion of a 49-bp telomeric sequence into the coding region of HIS4 strongly stimulates meiotic recombination and the local formation of meiosis-specific double-strand DNA breaks (DSBs). When strains are constructed in which both hotspots are heterozygous, hotspot activity is substantially less when the hotspots are on the same chromosome than when they are on opposite chromosomes.

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Genetics. 1997 Mar; 145(3): 661–670.
PMCID: PMC1207851
PMID: 9055076

Competition between Adjacent Meiotic Recombination Hotspots in the Yeast Saccharomyces Cerevisiae

Q. Q. Fan, F. Xu, M. A. White, and T. D. Petes
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Abstract

In a wild-type strain of Saccharomyces cerevisiae, a hotspot for meiotic recombination is located upstream of the HIS4 gene. An insertion of a 49-bp telomeric sequence into the coding region of HIS4 strongly stimulates meiotic recombination and the local formation of meiosis-specific double-strand DNA breaks (DSBs). When strains are constructed in which both hotspots are heterozygous, hotspot activity is substantially less when the hotspots are on the same chromosome than when they are on opposite chromosomes.

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Selected References

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