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Determination of the parental origin of sex-chromosome monosomy using restriction fragment length polymorphisms.

American Journal of Human Genetics, 01 Sep 1985, 37(5):965-972
PMID: 2996336 PMCID: PMC1684699

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Abstract 

The parental origin of the single X chromosome in sex-chromosome monosomy was evaluated by comparing restriction fragment length polymorphisms (RFLPs) of 10 spontaneous aborted 45,X conceptions with those of their parents. Seven X-linked marker loci were used, and we were able to specify the origin of the X in nine cases, with six being maternally and three paternally derived. These results demonstrate the efficiency of the technique and show that the single X chromosome in 45,X spontaneous abortions can be derived from either parent.

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Logo of ajhgGuide for AuthorsAbout this journalExplore this journalAmerican Journal of Human Genetics
Am J Hum Genet. 1985 Sep; 37(5): 965–972.
PMCID: PMC1684699
PMID: 2996336

Determination of the parental origin of sex-chromosome monosomy using restriction fragment length polymorphisms.

T Hassold, E Kumlin, N Takaesu, and M Leppert
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Abstract

The parental origin of the single X chromosome in sex-chromosome monosomy was evaluated by comparing restriction fragment length polymorphisms (RFLPs) of 10 spontaneous aborted 45,X conceptions with those of their parents. Seven X-linked marker loci were used, and we were able to specify the origin of the X in nine cases, with six being maternally and three paternally derived. These results demonstrate the efficiency of the technique and show that the single X chromosome in 45,X spontaneous abortions can be derived from either parent.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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NICHD NIH HHS (1)