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Table 1

Characterization of LFS heterozygotes

Cell populationPassageCell doubling time, hp53 genotypePloidy in colcemidClass of mutation
NHFp920+/+4n
SFp944+/248W4nClass I
O41p1760+/184T4nTruncation
JMLI*30184T/184T4nTruncation
174p1221+/175HPolyploidClass II
4404p1139+/175HPolyploidClass II
9136p1877+/245DPolyploidClass II
143Ap1126+/+/143APolyploidClass II
175Hp825+/+/175HPolyploidClass II
281Gp1124+/+/281GPolyploidClass II
*Immortal.