A checkpoint for autoreactivity in human IgM+ memory B cell development

doi:10.1084/jem.20052033

PMC full text:

J Exp Med. 2006 Feb 20; 203(2): 393–400.

doi: 10.1084/jem.20052033

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Figure 1.

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Ig gene features. (A) IgH V and (B) J gene repertoire and (C) IgH CDR3 length of antibodies from mature naive and IgM⁺ memory B cells. (D) The number of mutations and (E) frequency of mutations of VH, Vκ, and Vλ genes in antibodies from IgM⁺ memory B cells as calculatedby the number of replacement (R; black bar) and silent (S; white bar) nucleotide exchanges per base pair in FWRs and CDRs. The R/S ratio in each region is indicated.

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