| PMC full text: | Nat Chem Biol. Author manuscript; available in PMC 2010 Sep 1. Published in final edited form as:
|
Figure 2
Chemical phylogenetic analysis of HDACs identifies unexpected selectivity of HDAC inhibitors. (a) Hierarchical clustering of HDACs and a representative panel of structurally-diverse HDAC inhibitor tool and investigational compounds 1, 2, 7-20 weighted by inhibitory potency (Ki). Complete quantitative data are shown in Supplementary Table 1. Data based on mean values of triplicate measurements. (b,c) Chemical structure and enzymatic selectivity profile of (b) MS-275 19 and (c) SAHA 1, overlaying molecular phylogeny. HDAC dendrograms are adapted from Supplementary Figure 4. Circles are proportionate in size to Ki on a logarithmic scale, as shown.
