Figure 5.

Identification of resolution phase neutrophil migration dynamics with restriction to preferred movement channels. (a) Model selection: model 1 is pure-diffusion; model 2 is drift–diffusion; model 3 pure-diffusion with restriction and model 4 is drift–diffusion with restriction. (b) Estimated joint distribution of parameters for model 3 (left panel over full support of the uniform prior and right panel zoomed in). (c) Simulation of the pure-diffusion with restriction model, model 3 (red), and comparison with experimental observations (black). The shaded region (red) shows the 90% confidence range obtained from 1000 simulations using the MAP estimates of the diffusion–restriction parameters.