The superhealing MRL background improves muscular dystrophy

doi:10.1186/2044-5040-2-26

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Skelet Muscle. 2012; 2: 26.

Published online 2012 Dec 5. doi: 10.1186/2044-5040-2-26

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The MRL genome quantitatively reduces fibrosis in Sgcg mice. Hydroxyproline (HOP) is a measure of fibrosis and is represented on the y axis (mM/mg). In the heart, diaphragm and quadriceps muscles, fibrosis is significantly (p < 0.001) reduced in intercrossed Sgcg^MRL/D2 (D2/MRL) animals compared to Sgcg in the D2 (D2) background at 8 weeks. Fibrosis remains significantly (***p < 0.001) reduced in Sgcg^MRL/D2 animals at the 32-week time point.

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