| PMC full text: | Ann Biomed Eng. Author manuscript; available in PMC 2013 Jun 13. Published in final edited form as: Ann Biomed Eng. 2012 Apr; 40(4): 849–859. Published online 2012 Jan 24. doi: 10.1007/s10439-011-0507-y |
Figure 3
Schematic of ESL ligation and signaling of Mac-1 dependent VOC
Following white blood cell tethering by E-selectin a signal is transduced resulting in a conformational upshift in Mac-1 to high affinity that facilitates binding to specific ligands on platelets captured from the blood stream.
