Abstract

INTRODUCTION

Post-acne scarring is a very distressing problem. Atrophic acne scars are dermal depressions commonly caused by destruction of collagen after inflammatory acne.[1] Many therapeutic measures such as chemical peeling, subcision, dermabrasion, fillers and punch techniques have been performed to improve acne scarring but with sub-optimal outcomes.[2,3,4,5,6] Ablative lasers such as Er:YAG lasers or CO₂ lasers produce significant improvement at the cost of long recovery times and post-inflammatory hyperpigmentation.[7,8] Recently, newer techniques such as microneedling fractional radiofrequency (MFR) has been shown to be clinically efficient in managing acne scars without causing direct damage to the epidermis.[9]

MFR device works by creating radiofrequency thermal zones without epidermal injury. After damage to the reticular dermis, long-term dermal remodelling, neoelastogenesis, and neocollagenogenesis results in dermal thickening.[10]

MFR device was evaluated over a period of 1 year (Dec 2012 to Nov 2013) in 31 patients of skin type III–V with Grade 3 and 4 atrophic acne scars.

METHODS

A retrospective photographic analysis of 31 patients treated with MFR for facial atrophic acne scarring was done between November 2012 and December 2013. None of the patients had received any previous treatment for their acne scars. Patients were excluded if they had received treatment with any other lasers during treatment or follow-up period. Thirty-one patients (15 male and 16 female) met the inclusion criteria. The mean age was 27.2 years.

Patients had undergone four sessions of MFR treatment for their acne scars with an interval of 6 weeks between each session, since the time for collagen remodelling lasts around 4-6 weeks. Treatment regimen was individualised based on predominant scar type and scar depth. The procedure area was painted with povidone iodine and cleaned with rectified surgical spirit prior to the procedure.

Procedure was performed under topical anaesthesia or nerve blocks, using sterile precautions. Penetration depth was limited to 1.5 mm on forehead, temple areas and areas with bony prominences.

Patients with predominantly ice pick scars and mixed scarring were given a needle depth of 3.5 mm on the first pass, 2.5 mm on the 2^nd pass and 1.5 mm on the 3^rd pass with minimal or no overlapping.

Higher energy settings (35 W-40 W) at depths of 3.5 mm with successively lower energy levels (30 W-35 W, 25 W-30 W, respectively) were used at lower penetration depths to prevent epidermal coagulation.

Post-procedure pain was managed by oral non steroidal anti-inflammatory drugs (NSAIDs) for 2 to 5 days. Patients were advised strict sun protection along with re-epithelizing agents containing cyclopentasiloxane, cyclohexasiloxone and sodium hyaluronate.

Assessment of efficacy

Objective assessment of Physician scores of improvement was determined by global acne scarring classification of Goodman & Baron [Tables ​[Tables11 and ​and2a2a and ​andbb].[11,12]

Table 1

Goodman and Baron's qualitative acne scar grading system[11,12]

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Table 2

(a) Goodman and Baron's quantitative acne scar grading system[11,12]

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Table 2

(b) Assessment of improvement using Goodman and Baron's quantitative acne scar grading system

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RESULTS

All patients completed the study, including the 3-month follow-ups. Most patients had mixed types of atrophic acne scars, including ice pick, boxcar and rolling scars. MFR was associated with substantial improvement in the appearance of all types of acne scars, which included the softening of scar contours as well as reduction in scar depth.

Estimation of improvement with Goodman and Baron's Global qualitative Acne Scarring System was done. Out of 31 patients who completed the treatment, 14 patients had Grade 4, 17 patients had Grade 3 before treatment. The physician's assessment of response to treatment based on Goodman and Baron Qualitative scar grading system is summarised in Table 3. In patients with Grade 4 scars, 12 patients (85.71%) showed improvement by 2 grades, i.e. their scars improved from Grade 4 to Grade 2 of Goodman and Baron scale [Figure 1a and ​andb].b]. Two patients (14.28%) with Grade 4 scars showed improvement by 1 grade with scars being obvious at social distances of 50 cm or greater. In 17 patients with Grade 3 scars, 13 patients (76.47%) improved by 2 grades [Figure 2a and ​andb]b] and 4 patients (23.52%) showed improvement by 1 grade [Figure 3a and ​andb].b]. Rolling and box scars showed better response than ice-pick scars.

Table 3

Physician assessment response based on Goodman and Baron's qualitative acne scar grading

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Figure 1

(a) Grade 4 acne scars, (b) Improvement in acne scars from Grade 4 to Grade 2 after treatment

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Figure 2

(a) Grade 3 acne scars, (b) Improvement in acne scars from Grade 3 to Grade 1 after treatment

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Figure 3

(a) Grade 3 acne scars, (b) Improvement in acne scars from Grade 3 to Grade 2 after treatment

Estimation of improvement with Goodman and Baron's Global quantitative Acne Scarring System showed that 58% of the patients had moderate improvement, 29% had minimal improvement, 9% had good improvement and 3% showed very good improvement [Figure 4].

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Figure 4

Bar graph representing improvement in acne scars by Goodman and Baron's quantitative acne scar grading system

The treatment was generally well tolerated. All patients underwent treatment-related pain. All patients had reported mild erythema for two days, two patients had oedema for more than three days, five patients reported post inflammatory hyperpigmentation and two patients had track marks of the device probe [Figure 5]. Social activity could commence as early as one day after treatment.

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Figure 5

Adverse effect–track marks of the device probe

DISCUSSION

Acne scarring occurs subsequent to visible resolution of deep inflammation. Scarring may occur regardless of the severity of acne. Although acne scarring is likely to be associated more often with nodulocystic acne, it may occur in cases with only superficial forms of acne as well, especially when effective treatment is delayed.[13,14]

A study showed that approximately 16% of patients with acne seek proper treatment, and among those seeking such help, 74% wait greater than 12 months, 12% wait for 6 to 12 months, 6% wait for 6 months and only 7% wait for less than 3 months to be seen professionally for therapy of their acne.[15]

Atrophic acne scarring appears to be most common type associated with acne. The major clinical types of atrophic scars are ice pick, rolling or superficial and deep soft scars, and boxcar or depressed fibrotic scars. Although ablative and non-ablative laser skin resurfacing has greatly improved the treatment of atrophic acne scars, they are not without disadvantages.[14,16]

Ablative lasers such as CO₂ and Er:YAG laser have efficacy of 25-90% for treatment of acne scars but are associated with erythema for more than 3 months, dyspigmentation and scarring.[17]

Non-ablative lasers such as 1064 nm Nd YAG and 1450 nm diode lasers have an efficacy of 40-50% after a series of treatments, with effect only on shallow box scars with no significant epidermal improvement.[17,18]

In contrast to ablative and non ablative lasers, treatment with the MFR device can be controlled by varying the depth.

CONCLUSION

MFR treatment can be considered as an effective modality of treatment for moderate to severe acne scars in patients with an added advantage of minimal downtime and effective improvement.

Footnotes

REFERENCES