Glutamatergic transmission in drug reward: implications for drug addiction

doi:10.3389/fnins.2015.00404

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Front Neurosci. 2015; 9: 404.

Published online 2015 Nov 5. doi: 10.3389/fnins.2015.00404

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Table 2

Effects of pharmacological manipulation of glutamate transmission on drug-induced increase of nucleus accumbens dopamine levels using in vivo microdialysis.

Drug of abuse	Glutamate receptor/Transporter	Pharmacological class	Compound	Status of animal	Dose and mode of drug administration	Species/Strains	Effect on dopamine levels	References
Cocaine	NMDA	Antagonist	MK-801	Cocaine-naive	15 mg/kg; i.p.	Rats/Sprague-Dawley	No effect	Wolf et al., 1994
		Antagonist	Dizocilpine	Cocaine-naive	15 mg/kg; i.p.	Rats/Sprague-Dawley	No effect	Pierce et al., 1997
	mGlu2/3	NAAG peptidase inhibitor	2-PMPA	Cocaine-experienced	10 mg/kg; i.p.	Rats/Long-Evans	Decreased	Xi et al., 2010
	mGlu7	Positive allosteric modulator	AMN082	Cocaine-experienced	10 mg/kg; i.p.	Rats/Long-Evans	No effect	Li et al., 2009
Nicotine	NMDA	Antagonist	CGP39551	Nicotine-naive	0.6 mg/kg; s.c.	Rats/Wistar	Decreased	Kosowski et al., 2004
	NMDA (NR2B selective)	Antagonist	Ro 25-6981	Nicotine-naive	0.1 mg/kg; s.c.	Rats/Wistar	Increased	Kosowski and Liljequist, 2004
	AMPA	Antagonist	ZK200775	Nicotine-naive	Nicotine-naive	Rats/Wistar	Decreased	Kosowski et al., 2004
		Antagonist	NBQX	Nicotine-naive	Nicotine-naive	Rats/Wistar	No effect	Kosowski et al., 2004
	mGlu2/3	Agonist	LY379268	Nicotine-experienced	0.03 mg/kg; single intravenous self-infusion	Rats/Wistar	Decrease	D'Souza et al., 2011
	mGlu2/3	Agonist	LY379268	Nicotine-naive	0.4 mg/kg s.c.	Rats/Wistar	No effect	D'Souza et al., 2011
	mGlu5	Negative allosteric modulator	MPEP	Nicotine-experienced	0.4 mg/kg s.c.	Rats/Sprague-Dawley	Decreased	Tronci and Balfour, 2011

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