Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Polyclonal antibody directed against human RANTES ameliorates disease in the Lewis rat adjuvant-induced arthritis model.

Author information

Affiliations

  • 1. Department of Immunology, Berlex Biosciences, Richmond, California 94804, USA.
      Authors
    • Barnes DA 1
    (1 author)

The Journal of Clinical Investigation, 01 Jun 1998, 101(12):2910-2919
https://doi.org/10.1172/jci2172 PMID: 9637726 PMCID: PMC508883

Free full text in Europe PMC

Abstract 

Adjuvant-induced arthritis (AIA) is one of many animal models of rheumatoid arthritis, a disease characterized by a T-lymphocyte and macrophage cellular infiltrate. We have characterized the development of this disease model with respect to chemokine expression. Increased levels of two chemokines, RANTES, a T-lymphocyte and monocyte chemo-attractant, and KC a chemoattractant for neutrophils, were found in whole blood and in the joint. Surprisingly, levels of MIP-1alpha, another T-lymphocyte and monocyte chemoattractant, were unchanged throughout the course of the disease in whole blood and only slightly elevated in the joint. RANTES expression plays an important role in the disease since a polyclonal antibody to RANTES greatly ameliorated symptoms in animals induced for AIA and was found to be as efficacious as treatment with indomethacin, a non-steroidal anti inflammatory. Polyclonal antibodies to either MIP-1alpha or KC were ineffective. This is the first report to show the importance of RANTES in the development of AIA.

Free full text 

Logo of jcinvestThe Journal of Clinical Investigation
J Clin Invest. 1998 Jun 15; 101(12): 2910–2919.
PMCID: PMC508883
PMID: 9637726

Polyclonal antibody directed against human RANTES ameliorates disease in the Lewis rat adjuvant-induced arthritis model.

D A Barnes, J Tse, M Kaufhold, M Owen, J Hesselgesser, R Strieter, R Horuk, and H D Perez
Author information Copyright and License information Disclaimer

Abstract

Adjuvant-induced arthritis (AIA) is one of many animal models of rheumatoid arthritis, a disease characterized by a T-lymphocyte and macrophage cellular infiltrate. We have characterized the development of this disease model with respect to chemokine expression. Increased levels of two chemokines, RANTES, a T-lymphocyte and monocyte chemo-attractant, and KC a chemoattractant for neutrophils, were found in whole blood and in the joint. Surprisingly, levels of MIP-1alpha, another T-lymphocyte and monocyte chemoattractant, were unchanged throughout the course of the disease in whole blood and only slightly elevated in the joint. RANTES expression plays an important role in the disease since a polyclonal antibody to RANTES greatly ameliorated symptoms in animals induced for AIA and was found to be as efficacious as treatment with indomethacin, a non-steroidal anti inflammatory. Polyclonal antibodies to either MIP-1alpha or KC were ineffective. This is the first report to show the importance of RANTES in the development of AIA.

Full Text

The Full Text of this article is available as a PDF (6.0M).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Waller M. Methods of measurement of rheumatoid factor. Ann N Y Acad Sci. 1969 Dec 10;168(1):5–16. [Abstract] [Google Scholar]
  • Stastny P. HLA-D and Ia antigens in rheumatoid arthritis and systemic lupus erythematosus. Arthritis Rheum. 1978 Jun;21(5 Suppl):S139–S143. [Abstract] [Google Scholar]
  • Woodrow JC, Nichol FE, Zaphiropoulos G. DR antigens and rheumatoid arthritis: a study of two populations. Br Med J (Clin Res Ed) 1981 Nov 14;283(6302):1287–1288. [Europe PMC free article] [Abstract] [Google Scholar]
  • Fontana A, Hengartner H, Weber E, Fehr K, Grob PJ, Cohen G. Interleukin 1 activity in the synovial fluid of patients with rheumatoid arthritis. Rheumatol Int. 1982;2(2):49–53. [Abstract] [Google Scholar]
  • Houssiau FA, Devogelaer JP, Van Damme J, de Deuxchaisnes CN, Van Snick J. Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides. Arthritis Rheum. 1988 Jun;31(6):784–788. [Abstract] [Google Scholar]
  • Xu WD, Firestein GS, Taetle R, Kaushansky K, Zvaifler NJ. Cytokines in chronic inflammatory arthritis. II. Granulocyte-macrophage colony-stimulating factor in rheumatoid synovial effusions. J Clin Invest. 1989 Mar;83(3):876–882. [Europe PMC free article] [Abstract] [Google Scholar]
  • Firestein GS, Xu WD, Townsend K, Broide D, Alvaro-Gracia J, Glasebrook A, Zvaifler NJ. Cytokines in chronic inflammatory arthritis. I. Failure to detect T cell lymphokines (interleukin 2 and interleukin 3) and presence of macrophage colony-stimulating factor (CSF-1) and a novel mast cell growth factor in rheumatoid synovitis. J Exp Med. 1988 Nov 1;168(5):1573–1586. [Europe PMC free article] [Abstract] [Google Scholar]
  • Miossec P, Naviliat M, Dupuy d'Angeac A, Sany J, Banchereau J. Low levels of interleukin-4 and high levels of transforming growth factor beta in rheumatoid synovitis. Arthritis Rheum. 1990 Aug;33(8):1180–1187. [Abstract] [Google Scholar]
  • Saxne T, Palladino MA, Jr, Heinegård D, Talal N, Wollheim FA. Detection of tumor necrosis factor alpha but not tumor necrosis factor beta in rheumatoid arthritis synovial fluid and serum. Arthritis Rheum. 1988 Aug;31(8):1041–1045. [Abstract] [Google Scholar]
  • Firestein GS, Zvaifler NJ. How important are T cells in chronic rheumatoid synovitis? Arthritis Rheum. 1990 Jun;33(6):768–773. [Abstract] [Google Scholar]
  • Katsikis PD, Chu CQ, Brennan FM, Maini RN, Feldmann M. Immunoregulatory role of interleukin 10 in rheumatoid arthritis. J Exp Med. 1994 May 1;179(5):1517–1527. [Europe PMC free article] [Abstract] [Google Scholar]
  • Kasama T, Strieter RM, Lukacs NW, Lincoln PM, Burdick MD, Kunkel SL. Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis. J Clin Invest. 1995 Jun;95(6):2868–2876. [Europe PMC free article] [Abstract] [Google Scholar]
  • Oppenheim JJ, Zachariae CO, Mukaida N, Matsushima K. Properties of the novel proinflammatory supergene "intercrine" cytokine family. Annu Rev Immunol. 1991;9:617–648. [Abstract] [Google Scholar]
  • Schall TJ, Jongstra J, Dyer BJ, Jorgensen J, Clayberger C, Davis MM, Krensky AM. A human T cell-specific molecule is a member of a new gene family. J Immunol. 1988 Aug 1;141(3):1018–1025. [Abstract] [Google Scholar]
  • Brown KD, Zurawski SM, Mosmann TR, Zurawski G. A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes. J Immunol. 1989 Jan 15;142(2):679–687. [Abstract] [Google Scholar]
  • Zipfel PF, Balke J, Irving SG, Kelly K, Siebenlist U. Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new family of secreted factors. J Immunol. 1989 Mar 1;142(5):1582–1590. [Abstract] [Google Scholar]
  • Taub DD, Conlon K, Lloyd AR, Oppenheim JJ, Kelvin DJ. Preferential migration of activated CD4+ and CD8+ T cells in response to MIP-1 alpha and MIP-1 beta. Science. 1993 Apr 16;260(5106):355–358. [Abstract] [Google Scholar]
  • Schall TJ, Bacon K, Camp RD, Kaspari JW, Goeddel DV. Human macrophage inflammatory protein alpha (MIP-1 alpha) and MIP-1 beta chemokines attract distinct populations of lymphocytes. J Exp Med. 1993 Jun 1;177(6):1821–1826. [Europe PMC free article] [Abstract] [Google Scholar]
  • Schall TJ, Bacon K, Toy KJ, Goeddel DV. Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature. 1990 Oct 18;347(6294):669–671. [Abstract] [Google Scholar]
  • Bacon KB, Premack BA, Gardner P, Schall TJ. Activation of dual T cell signaling pathways by the chemokine RANTES. Science. 1995 Sep 22;269(5231):1727–1730. [Abstract] [Google Scholar]
  • Taub DD, Turcovski-Corrales SM, Key ML, Longo DL, Murphy WJ. Chemokines and T lymphocyte activation: I. Beta chemokines costimulate human T lymphocyte activation in vitro. J Immunol. 1996 Mar 15;156(6):2095–2103. [Abstract] [Google Scholar]
  • Horuk R. Molecular properties of the chemokine receptor family. Trends Pharmacol Sci. 1994 May;15(5):159–165. [Abstract] [Google Scholar]
  • Neote K, DiGregorio D, Mak JY, Horuk R, Schall TJ. Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. Cell. 1993 Feb 12;72(3):415–425. [Abstract] [Google Scholar]
  • Rathanaswami P, Hachicha M, Sadick M, Schall TJ, McColl SR. Expression of the cytokine RANTES in human rheumatoid synovial fibroblasts. Differential regulation of RANTES and interleukin-8 genes by inflammatory cytokines. J Biol Chem. 1993 Mar 15;268(8):5834–5839. [Abstract] [Google Scholar]
  • Snowden N, Hajeer A, Thomson W, Ollier B. RANTES role in rheumatoid arthritis. Lancet. 1994 Feb 26;343(8896):547–548. [Abstract] [Google Scholar]
  • Karpus WJ, Lukacs NW, McRae BL, Strieter RM, Kunkel SL, Miller SD. An important role for the chemokine macrophage inflammatory protein-1 alpha in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis. J Immunol. 1995 Nov 15;155(10):5003–5010. [Abstract] [Google Scholar]
  • PEARSON CM. Development of arthritis, periarthritis and periostitis in rats given adjuvants. Proc Soc Exp Biol Med. 1956 Jan;91(1):95–101. [Abstract] [Google Scholar]
  • Ackerman NR, Rooks WH, 2nd, Shott L, Genant H, Maloney P, West E. Effects of naproxen on connective tissue changes in the adjuvant arthritic rat. Arthritis Rheum. 1979 Dec;22(12):1365–1374. [Abstract] [Google Scholar]
  • Horuk R, Martin AW, Wang Z, Schweitzer L, Gerassimides A, Guo H, Lu Z, Hesselgesser J, Perez HD, Kim J, et al. Expression of chemokine receptors by subsets of neurons in the central nervous system. J Immunol. 1997 Mar 15;158(6):2882–2890. [Abstract] [Google Scholar]
  • Edwards SW, Hallett MB. Seeing the wood for the trees: the forgotten role of neutrophils in rheumatoid arthritis. Immunol Today. 1997 Jul;18(7):320–324. [Abstract] [Google Scholar]
  • Meade EA, Smith WL, DeWitt DL. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J Biol Chem. 1993 Mar 25;268(9):6610–6614. [Abstract] [Google Scholar]
  • Oliver SJ, Brahn E. Combination therapy in rheumatoid arthritis: the animal model perspective. J Rheumatol Suppl. 1996 Mar;44:56–60. [Abstract] [Google Scholar]
  • Horuk R, Martin A, Hesselgesser J, Hadley T, Lu ZH, Wang ZX, Peiper SC. The Duffy antigen receptor for chemokines: structural analysis and expression in the brain. J Leukoc Biol. 1996 Jan;59(1):29–38. [Abstract] [Google Scholar]
  • Darbonne WC, Rice GC, Mohler MA, Apple T, Hébert CA, Valente AJ, Baker JB. Red blood cells are a sink for interleukin 8, a leukocyte chemotaxin. J Clin Invest. 1991 Oct;88(4):1362–1369. [Europe PMC free article] [Abstract] [Google Scholar]
  • Marsh WL. Present status of the Duffy blood group system. CRC Crit Rev Clin Lab Sci. 1975 Mar;5(4):387–412. [Abstract] [Google Scholar]
  • Cook DN, Beck MA, Coffman TM, Kirby SL, Sheridan JF, Pragnell IB, Smithies O. Requirement of MIP-1 alpha for an inflammatory response to viral infection. Science. 1995 Sep 15;269(5230):1583–1585. [Abstract] [Google Scholar]
  • Gong JH, Ratkay LG, Waterfield JD, Clark-Lewis I. An antagonist of monocyte chemoattractant protein 1 (MCP-1) inhibits arthritis in the MRL-lpr mouse model. J Exp Med. 1997 Jul 7;186(1):131–137. [Europe PMC free article] [Abstract] [Google Scholar]
  • Yoshimura T, Robinson EA, Tanaka S, Appella E, Kuratsu J, Leonard EJ. Purification and amino acid analysis of two human glioma-derived monocyte chemoattractants. J Exp Med. 1989 Apr 1;169(4):1449–1459. [Europe PMC free article] [Abstract] [Google Scholar]
  • Plater-Zyberk C, Hoogewerf AJ, Proudfoot AE, Power CA, Wells TN. Effect of a CC chemokine receptor antagonist on collagen induced arthritis in DBA/1 mice. Immunol Lett. 1997 Jun 1;57(1-3):117–120. [Abstract] [Google Scholar]
Articles from The Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

Full text links 

Read article at publisher's site: https://doi.org/10.1172/jci2172

Read article for free, from open access legal sources, via Unpaywall: http://www.jci.org/articles/view/2172/files/pdfUnpaywall

Citations & impact 

Impact metrics

105
Citations
Jump to Citations
7
Data citations
Jump to Data

Citations of article over time

Alternative metrics

Altmetric item for https://www.altmetric.com/details/41108798
Altmetric
Discover the attention surrounding your research
https://www.altmetric.com/details/41108798

Article citations

Go to all (105) article citations

Data 

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.