Diverse and cancer type-specific roles of the p53 R248Q gain-of-function mutation in cancer migration and invasiveness

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Published online 2019 Feb 22. doi: 10.3892/ijo.2019.4723

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Table IV

Distribution of primary tumor types in patients with germline TP53 mutations.

p53 mutation	Sarcoma, n	Carcinoma, n	Other, n	P-value	Q
NULL	190	97	479	-	-
MIS^a	364	380	1266	<0.0001	0.0005
R248Q	21	7	55	0.5308	0.6635
R248W^a	16	19	77	0.0374	0.0623
R175H	27	14	77	0.8494	0.8494
R273H^a	29	17	41	0.0181	0.0453

^aP<0.05 and Q<0.1 vs. NULL group for primary tumor type. p53, tumor suppressor p53; MIS, any missense mutation.