Figure 3

(A) Loss of intermediate and nonclassical monocytes during the acute viremic phase followed by recovery, of first intermediate and then nonclassical monocytes, in convalescence. Quantitation of these cell populations as a percentage of CD45⁺CD66^– leukocytes is shown in graphs (range for all controls in gray). (B) CD14⁺ monocytes are actively proliferating (Ki-67⁺) during the acute phase at time points in which viral loads are declining. Samples from a control obtained on 3 separate dates are shown for comparison.