Toll-like receptor 1 as a possible target in non-alcoholic fatty liver disease

doi:10.1038/s41598-021-97346-9

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Sci Rep. 2021; 11: 17815.

Published online 2021 Sep 8. doi: 10.1038/s41598-021-97346-9

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Table 2

Effect of deletion of TLR1 on caloric intake, body- and liver weight and liver damage in FFC-fed mice.

	Wild-type		TLR1^−/−
	C	FFC	C	FFC
Caloric intake (kcal/g bw)	0.45±0.0	0.44±0.0	0.42±0.0	0.42±0.0
Body weight (g)	22.1±0.4	22.7±0.6	22.5±0.8	23.7±0.6
Liver weight (g)	1.2±0.1	1.6±0.1^a,c	1.1±0.1	1.5±0.1^a,c
Liver:body weight ratio (%)	5.3±0.2	6.9±0.2^a,c	4.9±0.2	6.5±0.2^a,c
ALT (U/l)	15.7±2.6	16.1±1.2	16.5±3.1	20.2±1.5
AST (U/l)	40.8±1.2	43.7±2.4	44.6±3.0	47.9±0.8
Fasted glucose concentration (mg/dl)	102.0±3.6	92.0±6.3	81.0±4.0	87.8±7.9
F4/80 mRNA expression (% of control)	100±6.0	192.1±18.5^a,c	112.1±77.8	158.4±17.8^a

Data are shown as means±SEM, n=5–6, ^ap≤0.05 compared to C-fed wild-type mice, ^cp≤0.05 compared to C-fed TLR1^−/− mice.

ALT alanine aminotransferase, AST aspartate aminotransferase, C control diet, FFC fat-, fructose-, and cholesterol-rich diet, TLR toll-like receptor.