Original research: Motor cortex functional connectivity is associated with underlying neurochemistry in ALS

doi:10.1136/jnnp-2022-329993

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J Neurol Neurosurg Psychiatry. 2023 Mar; 94(3): 193–200.

Published online 2022 Nov 15. doi: 10.1136/jnnp-2022-329993

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Table 3

Summary of structural and neurochemical measures in the PMC

Imaging metric	Mean±SE		p-value
Imaging metric	ALS	HC	p-value
Neurochemical ratios
tNAA/Cr	1.88±0.03	2.05±0.03	<0.001
tNAA/Cho	2.44±0.14	2.94±0.14	0.017
Diffusion in PMC WM
FA	0.38±0.00	0.41±0.00	<0.001
MD	(0.80±0.01)	(0.77±0.01)	<0.001
RD	(0.64±0.01)	(0.6±0.01)	0.022
AD	(1.12±0.01)	(1.12±0.01)	NS

MD, RD, AD are ×10⁻³ mm²/s. The boldened p-values indicate statistically significant group differences.

AD, axial diffusivity; Cho, choline; Cr, creatine; FA, fractional anisotropy; MD, mean diffusivity; PMC, primary motor cortex; RD, radial diffusivity; tNAA, total NAA moieties; WM, white matter.