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Search life-sciences literature (45,104,206 articles, preprints and more)

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GDF15 research from bench to bedside.
Breit SN, Brown DA, Tsai VWW
Cancer Cell, 42(11):1823-1824, 24 Oct 2024
Cited by: 0 articles | PMID: 39454578
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Humans without GDF15 reassure drug developers.
Breit SN, O'Rahilly S
Nat Metab, 6(10):1850-1851, 01 Oct 2024
Cited by: 0 articles | PMID: 39327532
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A Systematic Review of the Neuroprotective Role and Biomarker Potential of GDF15 in Neurodegeneration
Isik FI, Thomson S, Cueto JF, Spathos J, Breit SN, Tsai VW, Brown DA, Finney CA
bioRxiv, 09 Jul 2024
Cited by: 0 articles | PPR: PPR878310
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Clinical validation of circulating GDF15/MIC-1 as a marker of response to docetaxel and survival in men with metastatic castration-resistant prostate cancer.
Mahon KL, Sutherland SI, Lin HM, Stockler MR, Gurney H, Mallesara G, Briscoe K, Marx G, Higano CS, de Bono JS, Chi KN, Clark G, Breit SN, Brown DA, Horvath LG
Prostate, 84(8):747-755, 27 Mar 2024
Cited by: 1 article | PMID: 38544345
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GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway.
Breit SN, Manandhar R, Zhang HP, Lee-Ng M, Brown DA, Tsai VW
Cell Metab, 35(8):1341-1355.e3, 10 Jul 2023
Cited by: 8 articles | PMID: 37433299
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β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling.
Thai LM, O'Reilly L, Reibe-Pal S, Sue N, Holliday H, Small L, Schmitz-Peiffer C, Dhenni R, Wang-Wei Tsai V, Norris N, Yau B, Zhang X, Lee K, Yan C, Shi YC, Kebede MA, Brink R, Cooney GJ, Irvine KM, [...] Biden TJ
iScience, 26(4):106477, 22 Mar 2023
Cited by: 2 articles | PMID: 37091234 | PMCID: PMC10113792
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GDF15 analogs as obesity therapeutics.
Breit SN, Brown DA, Tsai VWW
Cell Metab, 35(2):227-228, 01 Feb 2023
Cited by: 6 articles | PMID: 36754014
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Associations of serum short-chain fatty acids with circulating immune cells and serum biomarkers in patients with multiple sclerosis.
Trend S, Leffler J, Jones AP, Cha L, Gorman S, Brown DA, Breit SN, Kermode AG, French MA, Ward NC, Hart PH
Sci Rep, 11(1):5244, 04 Mar 2021
Cited by: 33 articles | PMID: 33664396 | PMCID: PMC7933417
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This article is in the Europe PMC Open access subset. Refer to the copyright information in the article for licensing details.
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The GDF15-GFRAL Pathway in Health and Metabolic Disease: Friend or Foe?
Breit SN, Brown DA, Tsai VW
Annu Rev Physiol, 83:127-151, 23 Nov 2020
Cited by: 64 articles | PMID: 33228454
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Growth differentiation factor-15 slows the growth of murine prostate cancer by stimulating tumor immunity.
Husaini Y, Tsai VW, Manandhar R, Zhang HP, Lee-Ng KKM, Lebhar H, Marquis CP, Brown DA, Breit SN
PLoS One, 15(6):e0233846, 05 Jun 2020
Cited by: 14 articles | PMID: 32502202 | PMCID: PMC7274405
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MIC-1/GDF15 Overexpression Is Associated with Increased Functional Recovery in Traumatic Spinal Cord Injury.
Hassanpour Golakani M, Mohammad MG, Li H, Gamble J, Breit SN, Ruitenberg MJ, Brown DA
J Neurotrauma, 36(24):3410-3421, 01 Aug 2019
Cited by: 8 articles | PMID: 31232176
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GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS.
Tsai VW, Zhang HP, Manandhar R, Schofield P, Christ D, Lee-Ng KKM, Lebhar H, Marquis CP, Husaini Y, Brown DA, Breit SN
Int J Obes (Lond), 43(12):2370-2380, 31 May 2019
Cited by: 25 articles | PMID: 31152154
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Targeting the divergent TGFβ superfamily cytokine MIC-1/GDF15 for therapy of anorexia/cachexia syndromes.
Tsai VW, Brown DA, Breit SN
Curr Opin Support Palliat Care, 12(4):404-409, 01 Dec 2018
Cited by: 8 articles | PMID: 30382947
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The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases.
Tsai VWW, Husaini Y, Sainsbury A, Brown DA, Breit SN
Cell Metab, 28(3):353-368, 01 Sep 2018
Cited by: 176 articles | PMID: 30184485
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A Meta-Analysis of Genome-Wide Association Studies of Growth Differentiation Factor-15 Concentration in Blood.
Jiang J, Thalamuthu A, Ho JE, Mahajan A, Ek WE, Brown DA, Breit SN, Wang TJ, Gyllensten U, Chen MH, Enroth S, Januzzi JL, Lind L, Armstrong NJ, Kwok JB, Schofield PR, Wen W, Trollor JN, Johansson Å, [...] Mather KA
Front Genet, 9:97, 23 Mar 2018
Cited by: 17 articles | PMID: 29628937 | PMCID: PMC5876753
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Treatment with the TGF-b superfamily cytokine MIC-1/GDF15 reduces the adiposity and corrects the metabolic dysfunction of mice with diet-induced obesity.
Tsai VW, Zhang HP, Manandhar R, Lee-Ng KKM, Lebhar H, Marquis CP, Husaini Y, Sainsbury A, Brown DA, Breit SN
Int J Obes (Lond), 42(3):561-571, 05 Dec 2017
Cited by: 40 articles | PMID: 29026214
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Targeting Obesity and Cachexia: Identification of the GFRAL Receptor-MIC-1/GDF15 Pathway.
Breit SN, Tsai VW, Brown DA
Trends Mol Med, 23(12):1065-1067, 09 Nov 2017
Cited by: 33 articles | PMID: 29129392
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Macrophage inhibitory cytokine-1/growth differentiation factor-15 as a predictor of colonic neoplasia.
Danta M, Barber DA, Zhang HP, Lee-Ng M, Baumgart SWL, Tsai VWW, Husaini Y, Saxena M, Marquis CP, Errington W, Kerr S, Breit SN, Brown DA
Aliment Pharmacol Ther, 46(3):347-354, 01 Jun 2017
Cited by: 10 articles | PMID: 28569401
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First Behavioural Characterisation of a Knockout Mouse Model for the Transforming Growth Factor (TGF)-β Superfamily Cytokine, MIC-1/GDF15.
Low JK, Ambikairajah A, Shang K, Brown DA, Tsai VW, Breit SN, Karl T
PLoS One, 12(1):e0168416, 12 Jan 2017
Cited by: 4 articles | PMID: 28081177 | PMCID: PMC5231335
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Anorexia-cachexia syndrome in hepatoma tumour-bearing rats requires the area postrema but not vagal afferents and is paralleled by increased MIC-1/GDF15.
Borner T, Arnold M, Ruud J, Breit SN, Langhans W, Lutz TA, Blomqvist A, Riediger T
J Cachexia Sarcopenia Muscle, 8(3):417-427, 26 Dec 2016
Cited by: 21 articles | PMID: 28025863 | PMCID: PMC5476861
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Interaction of Human Chloride Intracellular Channel Protein 1 (CLIC1) with Lipid Bilayers: A Fluorescence Study.
Hare JE, Goodchild SC, Breit SN, Curmi PM, Brown LJ
Biochemistry, 55(27):3825-3833, 29 Jun 2016
Cited by: 11 articles | PMID: 27299171
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CLIC1 regulates dendritic cell antigen processing and presentation by modulating phagosome acidification and proteolysis.
Salao K, Jiang L, Li H, Tsai VW, Husaini Y, Curmi PM, Brown LJ, Brown DA, Breit SN
Biol Open, 5(5):620-630, 15 May 2016
Cited by: 23 articles | PMID: 27113959 | PMCID: PMC4874360
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Anorexia-cachexia and obesity treatment may be two sides of the same coin: role of the TGF-b superfamily cytokine MIC-1/GDF15.
Tsai VW, Lin S, Brown DA, Salis A, Breit SN
Int J Obes (Lond), 40(2):193-197, 01 Dec 2015
Cited by: 61 articles | PMID: 26620888
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Comparison of the Freelite serum free light chain (SFLC) assay with serum and urine electrophoresis/immunofixation and the N Latex FLC assay.
Sasson SC, McGill K, Wienholt L, Carr A, Brown DA, Kelleher AD, Breit SN, Sewell WA
Pathology, 47(6):564-569, 01 Oct 2015
Cited by: 9 articles | PMID: 26352111
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An inverse relationship between serum macrophage inhibitory cytokine-1 levels and brain white matter integrity in community-dwelling older individuals.
Jiang J, Trollor JN, Brown DA, Crawford JD, Thalamuthu A, Smith E, Breit SN, Liu T, Brodaty H, Baune BT, Sachdev PS, Wen W
Psychoneuroendocrinology, 62:80-88, 29 Jul 2015
Cited by: 9 articles | PMID: 26254771
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