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Search life-sciences literature (45,104,145 articles, preprints and more)

Suggested authors matching "AUTH:Hessel EM" with an ORCID

Edith M Hessel
GlaxoSmithKline Plc
47
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3,425
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The FAM13A Long Isoform Regulates Cilia Movement and Coordination in Airway Mucociliary Transport.
Howes A, Rogerson C, Belyaev N, Karagyozova T, Rapiteanu R, Fradique R, Pellicciotta N, Mayhew D, Hurd C, Crotta S, Singh T, Dingwell K, Myatt A, Arad N, Hasan H, Bijlsma H, Panjwani A, Vijayan V, Young G, [...] Wack A
Am J Respir Cell Mol Biol, 71(3):282-293, 01 Sep 2024
Cited by: 1 article | PMID: 38691660 | PMCID: PMC11376246
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In situ targeted base editing of bacteria in the mouse gut.
Brödel AK, Charpenay LH, Galtier M, Fuche FJ, Terrasse R, Poquet C, Havránek J, Pignotti S, Krawczyk A, Arraou M, Prevot G, Spadoni D, Yarnall MTN, Hessel EM, Fernandez-Rodriguez J, Duportet X, Bikard D
Nature, 632(8026):877-884, 10 Jul 2024
Cited by: 1 article | PMID: 38987595 | PMCID: PMC11338833
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A community effort to track commercial single-cell and spatial 'omic technologies and business trends.
De Jonghe J, Opzoomer JW, Vilas-Zornoza A, Crane P, Nilges BS, Vicari M, Lee H, Lara-Astiaso D, Gross T, Morf J, Schneider K, Cudini J, Ramos-Mucci L, Mooijman D, Tiklová K, Salas SM, Langseth CM, Kashikar ND, Roberts CES, [...] Taylor-King JP
Nat Biotechnol, 42(7):1017-1023, 01 Jul 2024
Cited by: 0 articles | PMID: 39020213
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PI4KIIIβ inhibition reduces rhinovirus associated cell shedding and ciliary dysfunction
Velkova SA, Petris AM, Lee DD, Cardinale D, Moulding D, Williamson RA, Beinke S, Grace K, Hessel EM, Belyaev NN, Hoegg T, Steiner M, Hurst JR, Smyth RL, Smith CM, Freestone P, O’Callaghan C
bioRxiv, 14 Dec 2023
Cited by: 0 articles | PPR: PPR773540
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Genome-wide association study of susceptibility to hospitalised respiratory infections
Williams AT, Shrine N, Naghra-van Gijzel H, Betts JC, Chen J, Hessel EM, John C, Packer R, Reeve NF, Yeo AJ, Abner E, Åsvold BO, Auvinen J, Bartz TM, Bradford Y, Brumpton B, Campbell A, Cho MH, Chu S, [...] Tobin MD
Wellcome Open Res, 21 Nov 2023
Cited by: 0 articles | PPR: PPR762594
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In situtargeted mutagenesis of gut bacteria
Brödel AK, Charpenay L, Galtier M, Fuche FJ, Terrasse R, Poquet C, Arraou M, Prevot G, Spadoni D, Hessel EM, Fernandez-Rodriguez J, Duportet X, Bikard D
bioRxiv, 30 Sep 2022
Cited by: 0 articles | PPR: PPR552783
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Distinct eosinophil subsets are modulated by agonists of the commensal-metabolite and vitamin B3 receptor GPR109A during allergic-type inflammation
Azzoni R, Filbey KJ, Daw RH, Krauss MZ, Hepworth MR, Konkel JE, Hessel EM, Kannan Y, Grainger JR
bioRxiv, 05 Aug 2022
Cited by: 0 articles | PPR: PPR528883
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PI3Kδ inhibition prevents IL33, ILC2s and inflammatory eosinophils in persistent airway inflammation.
Uddin S, Amour A, Lewis DJ, Edwards CD, Williamson MG, Hall S, Lione LA, Hessel EM
BMC Immunol, 22(1):78, 17 Dec 2021
Cited by: 4 articles | PMID: 34920698 | PMCID: PMC8684271
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Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode.
Down K, Amour A, Anderson NA, Barton N, Campos S, Cannons EP, Clissold C, Convery MA, Coward JJ, Doyle K, Duempelfeld B, Edwards CD, Goldsmith MD, Krause J, Mallett DN, McGonagle GA, Patel VK, Rowedder J, Rowland P, [...] Hessel EM
J Med Chem, 64(18):13780-13792, 11 Sep 2021
Cited by: 0 articles | PMID: 34510892
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Rhinovirus-induced Human Lung Tissue Responses Mimic Chronic Obstructive Pulmonary Disease and Asthma Gene Signatures.
Wronski S, Beinke S, Obernolte H, Belyaev NN, Saunders KA, Lennon MG, Schaudien D, Braubach P, Jonigk D, Warnecke G, Zardo P, Fieguth HG, Wilkens L, Braun A, Hessel EM, Sewald K
Am J Respir Cell Mol Biol, 65(5):544-554, 01 Nov 2021
Cited by: 10 articles | PMID: 34181859 | PMCID: PMC8641849
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Physiologically Based Pharmacokinetic Modelling of Inhaled Nemiralisib: Mechanistic Components for Pulmonary Absorption, Systemic Distribution, and Oral Absorption.
Miller NA, Graves RH, Edwards CD, Amour A, Taylor E, Robb O, O'Brien B, Patel A, Harrell AW, Hessel EM
Clin Pharmacokinet, 61(2):281-293, 30 Aug 2021
Cited by: 4 articles | PMID: 34458976 | PMCID: PMC8813803
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An Inhaled PI3Kδ Inhibitor Improves Recovery in Acutely Exacerbating COPD Patients: A Randomized Trial.
Cahn A, Hamblin JN, Robertson J, Begg M, Jarvis E, Wilson R, Dear G, Leemereise C, Cui Y, Mizuma M, Montembault M, Van Holsbeke C, Vos W, De Backer W, De Backer J, Hessel EM
Int J Chron Obstruct Pulmon Dis, 16:1607-1619, 03 Jun 2021
Cited by: 6 articles | PMID: 34113093 | PMCID: PMC8184151
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Nemiralisib in Patients with an Acute Exacerbation of COPD: Placebo-Controlled, Dose-Ranging Study.
Fahy WA, Homayoun-Valiani F, Cahn A, Robertson J, Templeton A, Meeraus WH, Wilson R, Lowings M, Marotti M, West SL, Tabberer M, Hessel EM
Int J Chron Obstruct Pulmon Dis, 16:1637-1646, 03 Jun 2021
Cited by: 6 articles | PMID: 34113095 | PMCID: PMC8184152
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Exploring PI3Kδ Molecular Pathways in Stable COPD and Following an Acute Exacerbation, Two Randomized Controlled Trials.
Begg M, Hamblin JN, Jarvis E, Bradley G, Mark S, Michalovich D, Lennon M, Wajdner HE, Amour A, Wilson R, Saunders K, Tanaka R, Arai S, Tang T, Van Holsbeke C, De Backer J, Vos W, Titlestad IL, FitzGerald JM, [...] Hessel EM
Int J Chron Obstruct Pulmon Dis, 16:1621-1636, 03 Jun 2021
Cited by: 8 articles | PMID: 34113094 | PMCID: PMC8184158
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PI3Kδ Inhibition Prevents IL33, ILC2s and Inflammatory Eosinophils in Persistent Airway Inflammation
Uddin S, Amour A, Lewis DJ, Edwards CD, Williamson MG, Hall S, Lione LA, Hessel EM
Research Square, 19 Feb 2021
Cited by: 0 articles | PPR: PPR286131
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Genome-wide association study of susceptibility to hospitalised respiratory infections.
Williams AT, Shrine N, Naghra-van Gijzel H, Betts JC, Chen J, Hessel EM, John C, Packer R, Reeve NF, Yeo AJ, Abner E, Åsvold BO, Auvinen J, Bartz TM, Bradford Y, Brumpton B, Campbell A, Cho MH, Chu S, [...] Tobin MD
Wellcome Open Res, 6:290, 01 Jan 2021
Cited by: 2 articles | PMID: 39220670 | PMCID: PMC11362726
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Predicting Re-Exacerbation Timing and Understanding Prolonged Exacerbations: An Analysis of Patients with COPD in the ECLIPSE Cohort.
Meeraus WH, Mullerova H, El Baou C, Fahey M, Hessel EM, Fahy WA
Int J Chron Obstruct Pulmon Dis, 16:225-244, 05 Feb 2021
Cited by: 6 articles | PMID: 33574663 | PMCID: PMC7872897
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Corrected Super-Resolution Microscopy Enables Nanoscale Imaging of Autofluorescent Lung Macrophages.
Ambrose AR, Dechantsreiter S, Shah R, Montero MA, Quinn AM, Hessel EM, Beinke S, Tannahill GM, Davis DM
Biophys J, 119(12):2403-2417, 18 Nov 2020
Cited by: 7 articles | PMID: 33217385 | PMCID: PMC7822748
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Intranasal Bifidobacterium longum protects against viral-induced lung inflammation and injury in a murine model of lethal influenza infection.
Groeger D, Schiavi E, Grant R, Kurnik-Łucka M, Michalovich D, Williamson R, Beinke S, Kiely B, Akdis CA, Hessel EM, Shanahan F, O' Mahony L
EBioMedicine, 60:102981, 11 Sep 2020
Cited by: 33 articles | PMID: 32927273 | PMCID: PMC7495089
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Highly efficient genome editing in primary human bronchial epithelial cells differentiated at air-liquid interface.
Rapiteanu R, Karagyozova T, Zimmermann N, Singh K, Wayne G, Martufi M, Belyaev NN, Hessel EM, Michalovich D, Macarron R, Rowan WC, Cairns WJ, Roger J, Betts J, Beinke S, Maratou K
Eur Respir J, 55(5):1900950, 21 May 2020
Cited by: 11 articles | PMID: 32060058
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Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection.
Aegerter H, Kulikauskaite J, Crotta S, Patel H, Kelly G, Hessel EM, Mack M, Beinke S, Wack A
Nat Immunol, 21(2):145-157, 13 Jan 2020
Cited by: 149 articles | PMID: 31932810 | PMCID: PMC6983324
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Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity Target.
Henley ZA, Amour A, Barton N, Bantscheff M, Bergamini G, Bertrand SM, Convery M, Down K, Dümpelfeld B, Edwards CD, Grandi P, Gore PM, Keeling S, Livia S, Mallett D, Maxwell A, Price M, Rau C, Reinhard FBM, [...] Hamblin JN
J Med Chem, 63(2):638-655, 08 Jan 2020
Cited by: 5 articles | PMID: 31855425
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Drug Interactions for Low-Dose Inhaled Nemiralisib: A Case Study Integrating Modeling, In Vitro, and Clinical Investigations.
Patel A, Wilson R, Harrell AW, Taskar KS, Taylor M, Tracey H, Riddell K, Georgiou A, Cahn AP, Marotti M, Hessel EM
Drug Metab Dispos, 48(4):307-316, 02 Feb 2020
Cited by: 3 articles | PMID: 32009006
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Converging TLR9 and PI3Kgamma signaling induces sterile inflammation and organ damage.
Lima BHF, Marques PE, Gomides LF, Mattos MS, Kraemer L, Queiroz-Junior CM, Lennon M, Hirsch E, Russo RC, Menezes GB, Hessel EM, Amour A, Teixeira MM
Sci Rep, 9(1):19085, 13 Dec 2019
Cited by: 7 articles | PMID: 31836766 | PMCID: PMC6910931
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Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients.
Michalovich D, Rodriguez-Perez N, Smolinska S, Pirozynski M, Mayhew D, Uddin S, Van Horn S, Sokolowska M, Altunbulakli C, Eljaszewicz A, Pugin B, Barcik W, Kurnik-Lucka M, Saunders KA, Simpson KD, Schmid-Grendelmeier P, Ferstl R, Frei R, Sievi N, [...] O'Mahony L
Nat Commun, 10(1):5711, 13 Dec 2019
Cited by: 97 articles | PMID: 31836714 | PMCID: PMC6911092
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1-25 of 73 results

1 2 3

Search life-sciences literature (45,104,145 articles, preprints and more)

Suggested authors matching "AUTH:Hessel EM" with an ORCID

Search results

The FAM13A Long Isoform Regulates Cilia Movement and Coordination in Airway Mucociliary Transport.

In situ targeted base editing of bacteria in the mouse gut.

A community effort to track commercial single-cell and spatial 'omic technologies and business trends.

PI4KIIIβ inhibition reduces rhinovirus associated cell shedding and ciliary dysfunction

Genome-wide association study of susceptibility to hospitalised respiratory infections

In situtargeted mutagenesis of gut bacteria

Distinct eosinophil subsets are modulated by agonists of the commensal-metabolite and vitamin B3 receptor GPR109A during allergic-type inflammation

PI3Kδ inhibition prevents IL33, ILC2s and inflammatory eosinophils in persistent airway inflammation.

Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode.

Rhinovirus-induced Human Lung Tissue Responses Mimic Chronic Obstructive Pulmonary Disease and Asthma Gene Signatures.

Physiologically Based Pharmacokinetic Modelling of Inhaled Nemiralisib: Mechanistic Components for Pulmonary Absorption, Systemic Distribution, and Oral Absorption.

An Inhaled PI3Kδ Inhibitor Improves Recovery in Acutely Exacerbating COPD Patients: A Randomized Trial.

Nemiralisib in Patients with an Acute Exacerbation of COPD: Placebo-Controlled, Dose-Ranging Study.

Exploring PI3Kδ Molecular Pathways in Stable COPD and Following an Acute Exacerbation, Two Randomized Controlled Trials.

PI3Kδ Inhibition Prevents IL33, ILC2s and Inflammatory Eosinophils in Persistent Airway Inflammation

Genome-wide association study of susceptibility to hospitalised respiratory infections.

Predicting Re-Exacerbation Timing and Understanding Prolonged Exacerbations: An Analysis of Patients with COPD in the ECLIPSE Cohort.

Corrected Super-Resolution Microscopy Enables Nanoscale Imaging of Autofluorescent Lung Macrophages.

Intranasal Bifidobacterium longum protects against viral-induced lung inflammation and injury in a murine model of lethal influenza infection.

Highly efficient genome editing in primary human bronchial epithelial cells differentiated at air-liquid interface.

Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection.

Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity Target.

Drug Interactions for Low-Dose Inhaled Nemiralisib: A Case Study Integrating Modeling, In Vitro, and Clinical Investigations.

Converging TLR9 and PI3Kgamma signaling induces sterile inflammation and organ damage.

Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients.

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