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Activating pyruvate kinase improves red blood cell integrity by reducing band 3 tyrosine phosphorylation.
Le K, Wang X, Chu J, Lundt M, Lee YY, Conrey A, Frey I, Giannini S, Kosinski PA, Hausman JM, Low PS, Jeffries N, Desai SA, Thein SL
Blood Adv, 8(21):5653-5662, 01 Nov 2024
Cited by: 1 article | PMID: 39265169 | PMCID: PMC11564025
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Mitapivat, a pyruvate kinase activator, improves transfusion burden and reduces iron overload in β-thalassemic mice.
Mattè A, Kosinski PA, Federti E, Dang L, Recchiuti A, Russo R, Siciliano A, Riccardi V, Janin A, Mucci M, Leboeuf C, Iolascon A, Brugnara C, De Franceschi L
Haematologica, 108(9):2535-2541, 01 Sep 2023
Cited by: 4 articles | PMID: 36794508
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A phase 1 dose escalation study of the pyruvate kinase activator mitapivat (AG-348) in sickle cell disease.
Xu JZ, Conrey A, Frey I, Gwaabe E, Menapace LA, Tumburu L, Lundt M, Lequang T, Li Q, Glass K, Dunkelberger EB, Iyer V, Mangus H, Kung C, Dang L, Kosinski PA, Hawkins P, Jeffries N, Eaton WA, Lay Thein S
Blood, 140(19):2053-2062, 01 Nov 2022
Cited by: 21 articles | PMID: 35576529 | PMCID: PMC9837441
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Safety and efficacy of mitapivat, an oral pyruvate kinase activator, in adults with non-transfusion dependent α-thalassaemia or β-thalassaemia: an open-label, multicentre, phase 2 study.
Kuo KHM, Layton DM, Lal A, Al-Samkari H, Bhatia J, Kosinski PA, Tong B, Lynch M, Uhlig K, Vichinsky EP
Lancet, 400(10351):493-501, 01 Aug 2022
Cited by: 22 articles | PMID: 35964609
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Mitapivat increases ATP and decreases oxidative stress and erythrocyte mitochondria retention in a SCD mouse model.
Quezado ZMN, Kamimura S, Smith M, Wang X, Heaven MR, Jana S, Vogel S, Zerfas P, Combs CA, Almeida LEF, Li Q, Quezado M, Horkayne-Szakaly I, Kosinski PA, Yu S, Kapadnis U, Kung C, Dang L, Wakim P, [...] Thein SL
Blood Cells Mol Dis, 95:102660, 12 Mar 2022
Cited by: 8 articles | PMID: 35366607 | PMCID: PMC9148618
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The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model.
Matte A, Federti E, Kung C, Kosinski PA, Narayanaswamy R, Russo R, Federico G, Carlomagno F, Desbats MA, Salviati L, Leboeuf C, Valenti MT, Turrini F, Janin A, Yu S, Beneduce E, Ronseaux S, Iatcenko I, Dang L, [...] De Franceschi L
J Clin Invest, 131(10):144206, 01 May 2021
Cited by: 24 articles | PMID: 33822774 | PMCID: PMC8121526
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Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy.
Rab MAE, Bos J, van Oirschot BA, van Straaten S, Kosinski PA, Chubukov V, Kim H, Mangus H, Schutgens REG, Pasterkamp G, Dang L, Kung C, van Beers EJ, van Wijk R
Blood, 137(21):2997-3001, 01 May 2021
Cited by: 14 articles | PMID: 33690814 | PMCID: PMC8160499
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AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes.
Rab MAE, Van Oirschot BA, Kosinski PA, Hixon J, Johnson K, Chubukov V, Dang L, Pasterkamp G, Van Straaten S, Van Solinge WW, Van Beers EJ, Kung C, Van Wijk R
Haematologica, 106(1):238-249, 01 Jan 2021
Cited by: 29 articles | PMID: 31974203 | PMCID: PMC7776327
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The pyruvate kinase (PK) to hexokinase enzyme activity ratio and erythrocyte PK protein level in the diagnosis and phenotype of PK deficiency.
Al-Samkari H, Addonizio K, Glader B, Morton DH, Chonat S, Thompson AA, Kuo KHM, Ravindranath Y, Wang H, Rothman JA, Kwiatkowski JL, Kung C, Kosinski PA, Al-Sayegh H, London WB, Grace RF
Br J Haematol, 192(6):1092-1096, 28 May 2020
Cited by: 8 articles | PMID: 32463523
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Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8⁺ T Cells.
Ma EH, Verway MJ, Johnson RM, Roy DG, Steadman M, Hayes S, Williams KS, Sheldon RD, Samborska B, Kosinski PA, Kim H, Griss T, Faubert B, Condotta SA, Krawczyk CM, DeBerardinis RJ, Stewart KM, Richer MJ, Chubukov V, [...] Jones RG
Immunity, 51(5):856-870.e5, 10 Oct 2019
Cited by: 198 articles | PMID: 31747582
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Phase 1 Single- and Multiple-Ascending-Dose Randomized Studies of the Safety, Pharmacokinetics, and Pharmacodynamics of AG-348, a First-in-Class Allosteric Activator of Pyruvate Kinase R, in Healthy Volunteers.
Yang H, Merica E, Chen Y, Cohen M, Goldwater R, Kosinski PA, Kung C, Yuan ZJ, Silverman L, Goldwasser M, Silver BA, Agresta S, Barbier AJ
Clin Pharmacol Drug Dev, 8(2):246-259, 09 Aug 2018
Cited by: 19 articles | PMID: 30091852
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AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency.
Kung C, Hixon J, Kosinski PA, Cianchetta G, Histen G, Chen Y, Hill C, Gross S, Si Y, Johnson K, DeLaBarre B, Luo Z, Gu Z, Yao G, Tang H, Fang C, Xu Y, Lv X, Biller S, [...] Dang L
Blood, 130(11):1347-1356, 31 Jul 2017
Cited by: 43 articles | PMID: 28760888 | PMCID: PMC5609468
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Heat shock protein 90 (HSP90) inhibitors activate the heat shock factor 1 (HSF1) stress response pathway and improve glucose regulation in diabetic mice.
Lee JH, Gao J, Kosinski PA, Elliman SJ, Hughes TE, Gromada J, Kemp DM
Biochem Biophys Res Commun, 430(3):1109-1113, 19 Dec 2012
Cited by: 29 articles | PMID: 23261432
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Uncovering mechanisms of transcriptional regulations by systematic mining of cis regulatory elements with gene expression profiles.
Ma Q, Chirn GW, Szustakowski JD, Bakhtiarova A, Kosinski PA, Kemp D, Nirmala N
BioData Min, 1(1):4, 17 Jul 2008
Cited by: 8 articles | PMID: 18822150 | PMCID: PMC2553773
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Dynamic resolution of functionally related gene sets in response to acute heat stress.
Szustakowski JD, Kosinski PA, Marrese CA, Lee JH, Elliman SJ, Nirmala N, Kemp DM
BMC Mol Biol, 8:46, 05 Jun 2007
Cited by: 9 articles | PMID: 17550601 | PMCID: PMC1904231
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Resveratrol inhibits firefly luciferase.
Bakhtiarova A, Taslimi P, Elliman SJ, Kosinski PA, Hubbard B, Kavana M, Kemp DM
Biochem Biophys Res Commun, 351(2):481-484, 18 Oct 2006
Cited by: 30 articles | PMID: 17064666
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Identification of novel pathway regulation during myogenic differentiation.
Szustakowski JD, Lee JH, Marrese CA, Kosinski PA, Nirmala NR, Kemp DM
Genomics, 87(1):129-138, 21 Nov 2005
Cited by: 28 articles | PMID: 16300922
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Contribution of human bone marrow stem cells to individual skeletal myotubes followed by myogenic gene activation.
Lee JH, Kosinski PA, Kemp DM
Exp Cell Res, 307(1):174-182, 08 Apr 2005
Cited by: 45 articles | PMID: 15922737
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Nucleolin is a second component of the CD154 mRNA stability complex that regulates mRNA turnover in activated T cells.
Singh K, Laughlin J, Kosinski PA, Covey LR
J Immunol, 173(2):976-985, 01 Jul 2004
Cited by: 40 articles | PMID: 15240685
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A complex containing polypyrimidine tract-binding protein is involved in regulating the stability of CD40 ligand (CD154) mRNA.
Kosinski PA, Laughlin J, Singh K, Covey LR
J Immunol, 170(2):979-988, 01 Jan 2003
Cited by: 36 articles | PMID: 12517964
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Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells.
Cioffi CL, Liu XQ, Kosinski PA, Garay M, Bowen BR
Biochem Biophys Res Commun, 303(3):947-953, 01 Apr 2003
Cited by: 105 articles | PMID: 12670503
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Identification of a complex that binds to the CD154 3' untranslated region: implications for a role in message stability during T cell activation.
Barnhart B, Kosinski PA, Wang Z, Ford GS, Kiledjian M, Covey LR
J Immunol, 165(8):4478-4486, 01 Oct 2000
Cited by: 26 articles | PMID: 11035087
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